Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, Uttarakhand, India.
Dalton Trans. 2017 Oct 24;46(41):14186-14191. doi: 10.1039/c7dt03278a.
Bio-inspired manganese Mn(NPy)(HO)(CHOH) (1) and iron [Fe(NPy)(HO)(ClO)]ClO (2) complexes derived from a pentadentate ligand (NPy = 2,6-bis((E)-1-phenyl-2-(pyridin-2-ylmethylene)hydrazinyl)pyridine) framework containing a N binding motif were synthesized and characterized using different spectroscopic methods. The molecular structures of complexes 1 and 2 were determined by X-ray crystallography. These complexes were found to be stable under physiological conditions and exhibited an excellent superoxide dismutase (SOD) activity. The SOD activity was determined by a xanthine-xanthine oxidase-nitro blue tetrazolium assay and the IC values were determined to be 1.53 and 2.09 μM, respectively.
受生物启发的锰Mn(NPy)(HO)(CHOH)（1）和铁[Fe(NPy)(HO)(ClO)]ClO（2）配合物由一个五齿配体（NPy=2,6-双（（E）-1-苯基-2-（吡啶-2-亚甲基）亚肼基）吡啶）框架衍生而来，该框架包含一个 N 结合基序。使用不同的光谱方法合成并表征了这些配合物。通过 X 射线晶体学确定了配合物 1 和 2 的分子结构。这些配合物在生理条件下稳定，并表现出出色的超氧化物歧化酶（SOD）活性。通过黄嘌呤-黄嘌呤氧化酶-硝基蓝四唑测定法测定 SOD 活性，IC 值分别为 1.53 和 2.09 μM。
