Department of Medical, Surgical, & Health Sciences, University of Trieste, Piazza Ospitale 1 34129 Trieste, Italy.
Department of Medical, Surgical, & Health Sciences, Teaching Hospital of Cattinara, University of Trieste, Via Fiume 447, 34129 Trieste, Italy.
Future Oncol. 2017 Oct;13(23):2083-2101. doi: 10.2217/fon-2017-0224. Epub 2017 Oct 6.
Malignant mesothelioma is a rare and aggressive form of cancer affecting the mesothelium. This mainly occupational disease is becoming more common in those countries where asbestos has been used for industrial applications. Notwithstanding the progress made in the field, patients do not survive more than 12 months on average with standard treatment. With the advent of next generation sequencing, it is now possible to study the mutational landscape of each tumor with the aim of identifying the genetic aberrations driving tumorigenesis. This review encompasses the latest research in the field, with particular attention to new chemotherapy combinatorial regimens, molecular targets and immunotherapies, providing a comprehensive picture of the current and future treatment options for malignant mesothelioma patients.
恶性间皮瘤是一种罕见且侵袭性的癌症，影响间皮。这种主要的职业病在石棉被用于工业应用的国家中越来越常见。尽管在该领域取得了进展，但采用标准治疗的患者平均生存期不超过 12 个月。随着下一代测序的出现，现在可以研究每个肿瘤的突变景观，以确定导致肿瘤发生的遗传异常。本综述涵盖了该领域的最新研究，特别关注新的化疗联合方案、分子靶点和免疫疗法，为恶性间皮瘤患者提供了当前和未来治疗选择的全面图景。
