Thompson Joyce K, Westbom Catherine M, Shukla Arti
Pathology Department, University of Vermont, College of Medicine, Burlington, Vermont.
J Cell Biochem. 2014 Jan;115(1):1-7. doi: 10.1002/jcb.24642.
Malignant mesothelioma (MM) is an aggressive cancer of the mesothelium caused by asbestos. Asbestos use has been reduced but not completely stopped. In addition, natural or man-made disasters will continue to dislodge asbestos from old buildings into the atmosphere and as long as respirable asbestos is available, MM will continue to be a threat. Due to the long latency period of MM development, it would still take decades to eradicate this disease if asbestos was completely removed from our lives today. Therefore, there is a need for researchers and clinicians to work together to understand this deadly disease and find a solution for early diagnosis and treatment. This article focuses on developmental mechanisms as well as current therapies available for MM.
恶性间皮瘤（MM）是一种由石棉引起的侵袭性间皮癌。石棉的使用已有所减少，但尚未完全停止。此外，自然或人为灾害将继续使石棉从旧建筑物中释放到大气中，只要有可吸入的石棉存在，MM就将继续构成威胁。由于MM发展的潜伏期很长，即使今天石棉已从我们的生活中完全消除，根除这种疾病仍需数十年时间。因此，研究人员和临床医生需要共同努力，了解这种致命疾病，并找到早期诊断和治疗的解决方案。本文重点关注MM的发病机制以及现有的治疗方法。
