VA San Diego Healthcare System.
Department of Psychiatry, University of California, San Diego, San Diego.
Alzheimer Dis Assoc Disord. 2018 Jan-Mar;32(1):50-56. doi: 10.1097/WAD.0000000000000215.
We examined associations between magnetic resonance imaging (MRI) markers of cerebrovascular disease and neurodegeneration with mild cognitive impairment (MCI) diagnosis at baseline and conversion from normal cognition to MCI at follow-up.
Framingham Offspring participants underwent brain MRI and neuropsychological assessment at baseline (n=1049) and follow-up (n=561). Participants were classified at baseline and at follow-up as cognitively normal or MCI using sensitive neuropsychological criteria. White matter hyperintensity (WMH) volume, covert brain infarcts, hippocampal volume, and total cerebral brain volume were quantified.
Baseline measures of WMH and hippocampal volume were associated with MCI status cross-sectionally and also with conversion from normal cognition to MCI at 6.5-year follow-up. Annualized change rates in total cerebral brain volume and hippocampal volume were associated with conversion from normal cognition to MCI to follow-up.
Baseline WMH and hippocampal volume are markers that are both associated with conversion from normal cognition to MCI, highlighting the role of both vascular lesions and neurodegeneration in MCI.
我们研究了基线时磁共振成像（MRI）脑血管病和神经退行性病变标志物与轻度认知障碍（MCI）诊断之间的关联，以及随访时从正常认知到 MCI 的转变。
弗雷明汉后代参与者在基线（n=1049）和随访（n=561）时接受脑部 MRI 和神经心理学评估。使用敏感的神经心理学标准，参与者在基线和随访时被分类为认知正常或 MCI。定量了脑白质高信号（WMH）体积、隐匿性脑梗死、海马体积和总脑体积。
基线时的 WMH 和海马体积与 MCI 状态的横断面有关，也与 6.5 年随访时从正常认知到 MCI 的转变有关。总脑体积和海马体积的年化变化率与从正常认知到 MCI 的随访转变有关。
基线时的 WMH 和海马体积是与从正常认知到 MCI 转变相关的标志物，突出了血管病变和神经退行性病变在 MCI 中的作用。
