超短回波时间 MRI 测量的软骨终板厚度变化与相邻椎间盘退变相关。
Cartilage Endplate Thickness Variation Measured by Ultrashort Echo-Time MRI Is Associated With Adjacent Disc Degeneration.
机构信息
Department of Orthopaedic Surgery, University of California, San Francisco, CA.
Department of Bioengineering, UC Berkeley/UCSF Joint Program in Bioengineering, Berkeley, CA.
出版信息
Spine (Phila Pa 1976). 2018 May 15;43(10):E592-E600. doi: 10.1097/BRS.0000000000002432.
STUDY DESIGN
A magnetic resonance imaging study of human cadaver spines.
OBJECTIVE
To investigate associations between cartilage endplate (CEP) thickness and disc degeneration.
SUMMARY OF BACKGROUND DATA
Damage to the CEP is associated with spinal injury and back pain. However, CEP morphology and its association with disc degeneration have not been well characterized.
METHODS
Ten lumbar motion segments with varying degrees of disc degeneration were harvested from six cadaveric spines and scanned with magnetic resonance imaging in the sagittal plane using a T2-weighted two-dimensional (2D) sequence, a three-dimensional (3D) ultrashort echo-time (UTE) imaging sequence, and a 3D T1ρ mapping sequence. CEP thicknesses were calculated from 3D UTE image data using a custom, automated algorithm, and these values were validated against histology measurements. Pfirrmann grades and T1ρ values in the disc were assessed and correlated with CEP thickness.
RESULTS
The mean CEP thickness calculated from UTE images was 0.74 ± 0.04 mm. Statistical comparisons between histology and UTE-derived measurements of CEP thickness showed significant agreement, with the mean difference not significantly different from zero (P = 0.32). Within-disc variation of T1ρ (standard deviation) was significantly lower for Pfirrmann grade 4 than Pfirrmann grade 3 (P < 0.05). Within-disc variation of T1ρ and adjacent CEP thickness heterogeneity (coefficient of variation) had a significant negative correlation (r = -0.65, P = 0.04). The standard deviation of T1ρand the mean CEP thickness showed a moderate positive correlation (r = 0.40, P = 0.26).
CONCLUSION
This study demonstrates that quantitative measurements of CEP thickness measured from UTE magnetic resonance imaging are associated with disc degeneration. Our results suggest that variability in CEP thickness and T1ρ, rather than their mean values, may serve as valuable diagnostic markers for disc degeneration.
LEVEL OF EVIDENCE
N/A.
研究设计
人体尸体脊柱的磁共振成像研究。
目的
研究软骨终板（CEP）厚度与椎间盘退变之间的关系。
背景资料概要
CEP 的损伤与脊柱损伤和背痛有关。然而，CEP 形态及其与椎间盘退变的关系尚未得到很好的描述。
方法
从 6 具尸体脊柱中采集了 10 个具有不同程度椎间盘退变的腰椎运动节段，并在矢状面使用 T2 加权二维（2D）序列、三维（3D）超短回波时间（UTE）成像序列和 3D T1ρ 映射序列进行磁共振成像扫描。使用定制的自动算法从 3D UTE 图像数据中计算 CEP 厚度，并将这些值与组织学测量值进行验证。评估椎间盘的 Pfirrmann 分级和 T1ρ 值，并与 CEP 厚度相关联。
结果
从 UTE 图像计算得出的 CEP 平均厚度为 0.74±0.04mm。组织学与 UTE 衍生的 CEP 厚度测量值之间的统计比较显示出显著的一致性，平均差值与零无显著差异（P=0.32）。与 Pfirrmann 分级 3 相比，Pfirrmann 分级 4 椎间盘内 T1ρ（标准差）的变异性显著降低（P<0.05）。椎间盘内 T1ρ 和相邻 CEP 厚度异质性（变异系数）的变异性呈显著负相关（r=-0.65，P=0.04）。T1ρ 的标准差和 CEP 厚度的平均值呈中度正相关（r=0.40，P=0.26）。
结论
本研究表明，从 UTE 磁共振成像测量的 CEP 厚度的定量测量与椎间盘退变有关。我们的结果表明，CEP 厚度和 T1ρ 的变异性而不是它们的平均值，可能是椎间盘退变的有价值的诊断标志物。
证据水平
N/A。
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