Cheng Xiaolong, Hu Zhenli, Han Yi-Ping, Bai Chong
Department of General Practice Department of Respiratory Medicine, Changhai Hospital, The Second Military Medical University, Shanghai, China.
Medicine (Baltimore). 2017 Oct;96(40):e8208. doi: 10.1097/MD.0000000000008208.
Tongue metastasis from lung cancer is extremely rare, and the prognosis of these patients is rather poor.
A 56-year-old man was found a 4-cm cavity lesion in the left upper lobe, which was initially misdiagnosed as tuberculosis.
A case of lung squamous cell carcinoma that metastasized to the base of a patient's tongue.
We send the biopsy of the lung and the tongue lesions for gene sequencing.
He received systemic chemotherapy, but continued to have pain at the base of his tongue and died 7 months later.
From sequencing data, mutations in KRAS proto-oncogene, GTPase (KRAS), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), and tumor protein p53 (TP53) were found in the tumor biopsy of the patient. All of these were indicators of poor prognosis.
肺癌发生舌部转移极为罕见，且这些患者的预后相当差。
一名56岁男性左上叶发现一个4厘米的空洞性病变，最初被误诊为肺结核。
一例肺鳞状细胞癌转移至患者舌根部。
我们将肺部和舌部病变的活检样本送去进行基因测序。
他接受了全身化疗，但舌根部持续疼痛，7个月后死亡。
从测序数据中发现，患者肿瘤活检中存在KRAS原癌基因、GTP酶（KRAS）、磷脂酰肌醇-4,5-二磷酸3-激酶催化亚基α（PIK3CA）和肿瘤蛋白p53（TP53）的突变。所有这些都是预后不良的指标。
