College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University , Jinan 250014, People's Republic of China.
Shandong Qianfoshan Hospital , Jinan 250014, People's Republic of China.
Inorg Chem. 2017 Nov 6;56(21):13241-13248. doi: 10.1021/acs.inorgchem.7b02012. Epub 2017 Oct 6.
Fluorescent probes are powerful tools for the investigations of reactive oxygen species (ROS) in living organisms by visualization and imaging. As one of the most important of the natural reactive oxygen species (ROS), hypochlorous acid (HClO) plays a crucial role in various physiological and pathological processes. We report herein a new redox-switchable NMOF of UiO-68-ol via a direct ligand modification approach. The obtained UiO-68-ol NPs, which contains organic-based molecular redox switches, exhibit excellent photophysical properties for biological application and can be highly sensitive and selective fluorescent probes to detect HClO species in living cells.
荧光探针是通过可视化和成像研究活生物体中活性氧（ROS）的有力工具。次氯酸（HClO）作为最重要的天然活性氧（ROS）之一，在各种生理和病理过程中起着至关重要的作用。我们在此报告了一种通过直接配体修饰方法合成的新型UiO-68-ol 的氧化还原开关型 NM OF。所得的UiO-68-ol NPs 含有基于有机分子的氧化还原开关，具有优异的生物应用光物理性质，并且可以作为高灵敏度和选择性的荧光探针，用于检测活细胞中的 HClO 物质。
