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GDF15 and energy balance: homing in on a mechanism.

作者信息

Cimino Irene, Coll Anthony P, Yeo Giles S H

机构信息

MRC Metabolic Diseases Unit and Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital Cambridge, Cambridge, UK.

出版信息

Nat Med. 2017 Oct 6;23(10):1119-1120. doi: 10.1038/nm.4414.

DOI:10.1038/nm.4414
PMID:28985212
Abstract
摘要

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1
GDF15 and energy balance: homing in on a mechanism.生长分化因子15与能量平衡:探寻一种机制
Nat Med. 2017 Oct 6;23(10):1119-1120. doi: 10.1038/nm.4414.
2
GDF15 mediates the effects of metformin on body weight and energy balance.GDF15 介导二甲双胍对体重和能量平衡的影响。
Nature. 2020 Feb;578(7795):444-448. doi: 10.1038/s41586-019-1911-y. Epub 2019 Dec 25.
3
GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.GFRAL 是 GDF15 的受体,是配体发挥抗肥胖作用所必需的。
Nat Med. 2017 Oct;23(10):1158-1166. doi: 10.1038/nm.4394. Epub 2017 Aug 28.
4
Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI.人MIC-1/GDF15的血清水平呈昼夜变化模式,未显示出提示饱腹感因子的特征,且与体重指数相关。
PLoS One. 2015 Jul 24;10(7):e0133362. doi: 10.1371/journal.pone.0133362. eCollection 2015.
5
Stress-induced FGF21 and GDF15 in obesity and obesity resistance.应激诱导的成纤维细胞生长因子21和生长分化因子15在肥胖及肥胖抵抗中的作用
Trends Endocrinol Metab. 2021 Nov;32(11):904-915. doi: 10.1016/j.tem.2021.08.008. Epub 2021 Sep 13.
6
The Role of Growth Differentiation Factor 15 in Energy Metabolism.生长分化因子 15 在能量代谢中的作用。
Diabetes Metab J. 2020 Jun;44(3):363-371. doi: 10.4093/dmj.2020.0087.
7
Treatment with the TGF-b superfamily cytokine MIC-1/GDF15 reduces the adiposity and corrects the metabolic dysfunction of mice with diet-induced obesity.MIC-1/GDF15 是 TGF-b 超家族细胞因子,用其治疗可减少饮食诱导肥胖小鼠的肥胖程度,并纠正其代谢功能障碍。
Int J Obes (Lond). 2018 Mar;42(3):561-571. doi: 10.1038/ijo.2017.258. Epub 2017 Dec 5.
8
GDF15, an update of the physiological and pathological roles it plays: a review.生长分化因子 15:对其生理病理作用的更新认识:综述
Pflugers Arch. 2020 Nov;472(11):1535-1546. doi: 10.1007/s00424-020-02459-1. Epub 2020 Sep 16.
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Weight Loss Induced by Bariatric Surgery Restricts Hepatic Expression.减肥手术引起的体重减轻会限制肝脏表达。
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The GDF15-GFRAL pathway is dispensable for the effects of metformin on energy balance.GDF15-GFRAL 通路对于二甲双胍对能量平衡的影响是可有可无的。
Cell Rep. 2022 Aug 23;40(8):111258. doi: 10.1016/j.celrep.2022.111258.

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Association between eating speed and atherosclerosis in relation to growth differentiation factor-15 levels in older individuals in a cross-sectional study.一项横断面研究中老年人进食速度与动脉粥样硬化及生长分化因子-15水平之间的关联
Sci Rep. 2024 Jul 17;14(1):16492. doi: 10.1038/s41598-024-67187-3.
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Whole genome sequencing of mouse lines divergently selected for fatness (FLI) and leanness (FHI) revealed several genetic variants as candidates for novel obesity genes.对肥胖(FLI)和瘦体(FHI)选择的小鼠系进行全基因组测序,发现了几个遗传变异作为新的肥胖基因候选。
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本文引用的文献

1
GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.GFRAL 是 GDF15 的受体,是配体发挥抗肥胖作用所必需的。
Nat Med. 2017 Oct;23(10):1158-1166. doi: 10.1038/nm.4394. Epub 2017 Aug 28.
2
The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.GDF15 的代谢作用是由孤儿受体 GFRAL 介导的。
Nat Med. 2017 Oct;23(10):1215-1219. doi: 10.1038/nm.4393. Epub 2017 Aug 28.
3
GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates.
Diltiazem inhibits breast cancer metastasis via mediating growth differentiation factor 15 and epithelial-mesenchymal transition.
地尔硫䓬通过介导生长分化因子15和上皮-间质转化来抑制乳腺癌转移。
Oncogenesis. 2022 Aug 13;11(1):48. doi: 10.1038/s41389-022-00423-5.
4
Camptothecin effectively treats obesity in mice through GDF15 induction.喜树碱通过诱导 GDF15 有效治疗肥胖症小鼠。
PLoS Biol. 2022 Feb 24;20(2):e3001517. doi: 10.1371/journal.pbio.3001517. eCollection 2022 Feb.
5
Pathophysiological role of growth differentiation factor 15 (GDF15) in obesity, cancer, and cachexia.生长分化因子 15(GDF15)在肥胖症、癌症和恶病质中的病理生理学作用。
Cytokine Growth Factor Rev. 2022 Apr;64:71-83. doi: 10.1016/j.cytogfr.2021.11.002. Epub 2021 Nov 17.
6
Multifaceted Mechanisms of Action of Metformin Which Have Been Unraveled One after Another in the Long History.二甲双胍的多方面作用机制在漫长的历史中一个接一个地被揭示出来。
Int J Mol Sci. 2021 Mar 5;22(5):2596. doi: 10.3390/ijms22052596.
7
Regulation of diurnal energy balance by mitokines.由细胞因子调节日间能量平衡。
Cell Mol Life Sci. 2021 Apr;78(7):3369-3384. doi: 10.1007/s00018-020-03748-9. Epub 2021 Jan 19.
8
Renoprotective and Immunomodulatory Effects of GDF15 following AKI Invoked by Ischemia-Reperfusion Injury.缺血再灌注损伤诱导的急性肾损伤后 GDF15 的肾保护和免疫调节作用。
J Am Soc Nephrol. 2020 Apr;31(4):701-715. doi: 10.1681/ASN.2019090876. Epub 2020 Feb 7.
9
The Global Epidemic of the Metabolic Syndrome.代谢综合征的全球流行。
Curr Hypertens Rep. 2018 Feb 26;20(2):12. doi: 10.1007/s11906-018-0812-z.
GFRAL 是 GDF15 的受体,该配体可促进小鼠和非人灵长类动物的体重减轻。
Nat Med. 2017 Oct;23(10):1150-1157. doi: 10.1038/nm.4392. Epub 2017 Aug 28.
4
Anorexia-cachexia and obesity treatment may be two sides of the same coin: role of the TGF-b superfamily cytokine MIC-1/GDF15.厌食-恶病质和肥胖症的治疗可能是同一问题的两个方面:TGF-β 超家族细胞因子 MIC-1/GDF15 的作用。
Int J Obes (Lond). 2016 Feb;40(2):193-7. doi: 10.1038/ijo.2015.242. Epub 2015 Dec 1.
5
Concise review: growth differentiation factor 15 in pathology: a clinical role?简明综述:生长分化因子 15 在病理学中的作用:具有临床意义?
Stem Cells Transl Med. 2013 Dec;2(12):946-52. doi: 10.5966/sctm.2013-0055. Epub 2013 Nov 4.
6
TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator.转化生长因子-β超家族细胞因子 MIC-1/GDF15 是一种生理性食欲和体重调节剂。
PLoS One. 2013;8(2):e55174. doi: 10.1371/journal.pone.0055174. Epub 2013 Feb 28.
7
Macrophage inhibitory cytokine 1 (MIC-1/GDF15) decreases food intake, body weight and improves glucose tolerance in mice on normal & obesogenic diets.巨噬细胞抑制细胞因子 1(MIC-1/GDF15)可降低正常和致肥胖饮食小鼠的食物摄入量、体重,并改善其葡萄糖耐量。
PLoS One. 2012;7(4):e34868. doi: 10.1371/journal.pone.0034868. Epub 2012 Apr 13.
8
Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1.肿瘤诱导的厌食和体重减轻由转化生长因子-β超家族细胞因子MIC-1介导。
Nat Med. 2007 Nov;13(11):1333-40. doi: 10.1038/nm1677. Epub 2007 Nov 4.
9
The GDNF family: signalling, biological functions and therapeutic value.胶质细胞源性神经营养因子家族:信号传导、生物学功能及治疗价值
Nat Rev Neurosci. 2002 May;3(5):383-94. doi: 10.1038/nrn812.
10
MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily.巨噬细胞抑制细胞因子1(MIC-1)是一种新型的巨噬细胞抑制细胞因子,属于转化生长因子-β(TGF-β)超家族中的一个不同成员。
Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11514-9. doi: 10.1073/pnas.94.21.11514.