Lloyd G, Atkinson T, Sutton P M
Division of Pathology, PHLS Centre for Applied Microbiology and Research, Salisbury, Wiltshire.
Lancet. 1988 Jun 25;1(8600):1418-21. doi: 10.1016/s0140-6736(88)92236-2.
Bile salts completely inactivated human immunodeficiency virus type 1 (HIV-1) in vitro and, unexpectedly, completely destroyed all the cultured persistently HIV-1 infected T cells. Fusidic acid, which likewise possesses the properties of an anionic surfactant, inactivated HIV-1 only at concentrations toxic to uninfected cultured cells. Bile salts or their derivatives, and other anionic surfactants, could be of therapeutic value in HIV-1 infections.
胆盐在体外可使1型人类免疫缺陷病毒（HIV-1）完全失活，且出乎意料的是，它能完全破坏所有培养的持续感染HIV-1的T细胞。同样具有阴离子表面活性剂特性的夫西地酸，只有在对未感染的培养细胞有毒性的浓度下才能使HIV-1失活。胆盐及其衍生物，以及其他阴离子表面活性剂，可能在HIV-1感染的治疗中具有应用价值。
