Delage Y, Dumont M, Erlinger S
Am J Physiol. 1976 Dec;231(6):1875-8. doi: 10.1152/ajplegacy.1976.231.6.1875.
The effect on sulfobromophathalein transport maximum (Tm) and biliary lipid secretion of sodium glyco-24,25-dihydrofusicate, a micelle-forming compound secreted into bile, has been studied in the hamster and compared to that of a physiological bile salt, sodium taurocholate. Biliary phospholipid and cholesterol secretion increased both during glycodihydrofusidate and taurocholate administration, an observation which suggest that both compounds increased th biliary secretion of micelle-forming compounds. In contrast, only taurocholate increased sulfobromophthalein Tm into bile, while glycodihydrofusidate administration decreased it. This observation suggests that the increase in sulfobromophthalein Tm observed during taurocholate administration is not the result of micellar sequestration. It could rather be the consequence of a specific effect of bile salts on the dye transport system.
已在家鼠身上研究了糖基-24,25-二氢fusicate钠（一种分泌到胆汁中的形成微胶粒的化合物）对磺溴酞钠转运极限（Tm）和胆汁脂质分泌的影响，并与生理胆汁盐牛磺胆酸钠进行了比较。在给予二氢fusicate糖酯和牛磺胆酸盐期间，胆汁磷脂和胆固醇分泌均增加，这一观察结果表明这两种化合物均增加了形成微胶粒化合物的胆汁分泌。相比之下，只有牛磺胆酸盐增加了磺溴酞钠进入胆汁的Tm，而给予二氢fusicate糖酯则使其降低。这一观察结果表明，在给予牛磺胆酸盐期间观察到的磺溴酞钠Tm增加并非微胶粒螯合的结果。它更可能是胆汁盐对染料转运系统特定作用的结果。
