Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1400 NW 10th Avenue, Dominion Tower 404A, Miami, FL, 33136, USA.
Department of Psychology, University of Georgia, Athens, GA, USA.
AIDS Behav. 2018 Jun;22(6):1766-1774. doi: 10.1007/s10461-017-1925-0.
HIV-exposed infants born to depressed women may be at risk for adverse developmental outcomes. Half of HIV-infected women in rural South Africa (SA) may suffer from pregnancy-related depression. This pilot study examined the impact of depression in HIV-infected women in rural SA on infant development. Mother-infant dyads (N = 69) were recruited in rural SA. Demographics, HIV disclosure, depression, male involvement, and alcohol use at baseline (18.35 ± 5.47 weeks gestation) were assessed. Male involvement, depression, infant HIV serostatus and development were assessed 12 months postnatally. Half of the women (age = 29 ± 5) reported depression prenatally and one-third reported depression postnatally. In multivariable logistic regression, not cohabiting with their male partner, nondisclosure of HIV status, and postnatal depression predicted cognitive delay; decreased prenatal male involvement predicted delayed gross motor development (ps < 0.05). Assessing pregnancy-related depression among HIV-infected women and infant development and increasing male involvement may reduce negative developmental outcomes among HIV-exposed or infected infants.
HIV 暴露婴儿的母亲患有抑郁症可能会导致其发育不良。南非农村地区有一半的 HIV 感染妇女可能患有与妊娠相关的抑郁症。本研究旨在探讨南非农村地区 HIV 感染妇女的抑郁状况对婴儿发育的影响。研究招募了 69 对母婴对，对其人口统计学资料、HIV 病毒暴露、抑郁、男性参与度和饮酒情况进行了基线评估（妊娠 18.35±5.47 周），并在婴儿出生后 12 个月时对其男性参与度、抑郁、婴儿 HIV 感染状况和发育情况进行了评估。一半的母亲（年龄 29±5 岁）在产前就报告有抑郁症状，三分之一的母亲在产后报告有抑郁症状。多变量逻辑回归显示，与男性伴侣分居、未告知 HIV 状况和产后抑郁会导致认知发育迟缓；产前男性参与度下降会导致粗大运动发育迟缓（p<0.05）。评估 HIV 感染妇女的妊娠相关抑郁情况和婴儿发育情况，并增加男性参与度，可能会降低 HIV 暴露或感染婴儿的不良发育结果。
