Addressing challenges in the clinical applications associated with CRISPR/Cas9 technology and ethical questions to prevent its misuse.
作者信息
Kang Xiang Jin, Caparas Chiong Isabella Noelle, Soh Boon Seng, Fan Yong
机构信息
Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, Center for Reproductive Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
Disease Modeling and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology, 61 Biopolis Drive Proteos, Singapore, 138673, Singapore.
出版信息
Protein Cell. 2017 Nov;8(11):791-795. doi: 10.1007/s13238-017-0477-4.
Abstract
摘要
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本文引用的文献
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Correction of a pathogenic gene mutation in human embryos.人类胚胎中致病基因突变的纠正。
Nature. 2017 Aug 24;548(7668):413-419. doi: 10.1038/nature23305. Epub 2017 Aug 2.
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CRISPR/Cas9-mediated gene editing in human zygotes using Cas9 protein.使用Cas9蛋白对人类受精卵进行CRISPR/Cas9介导的基因编辑。
Mol Genet Genomics. 2017 Jun;292(3):525-533. doi: 10.1007/s00438-017-1299-z. Epub 2017 Mar 1.
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Promoting Cas9 degradation reduces mosaic mutations in non-human primate embryos.促进 Cas9 降解可减少非人类灵长类动物胚胎中的镶嵌突变。
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Applications of CRISPR technologies in research and beyond.CRISPR技术在研究及其他领域的应用。
Nat Biotechnol. 2016;34(9):933-941. doi: 10.1038/nbt.3659. Epub 2016 Sep 8.
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CRISPR/Cas9 in Genome Editing and Beyond.CRISPR/Cas9 在基因组编辑及其他领域的应用
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Introducing precise genetic modifications into human 3PN embryos by CRISPR/Cas-mediated genome editing.通过CRISPR/Cas介导的基因组编辑将精确的基因修饰引入人类三原核胚胎。
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