Rutkofsky Ian Hunter, Khan Anser Saeed, Sahito Sindhu, Kumar Vikram
Adv Mind Body Med. 2017;31(3):8-16.
Context • Psychoneuroimmunology is the interdisciplinary study that links behavioral health with the neuroendocrinal system and investigates that link's bidirectional impact on the human immune system. Mechanistic studies have shown how omega-3 polyunsaturated fatty acids (PUFAs), like those found in fish oil, can modulate key pathways involved in inflammation, sympathetic activity, oxidative stress, transcription factors, and inflammatory cytokine production. Objective • The research team intended to investigate the effects that PUFAs have on the brain and the immune system, including the effects of proinflammatory cytokines and oxidative stress, and their therapeutic benefits in major depressive disorder (MDD) and bipolar disorder, either as an alternative monotherapy or a complementary adjunct treatment. Design • A literature search was conducted through PubMed and Google Scholar, with no restrictions on the publication dates or geographically. Setting • The research occurred at research facilities in Washington, DC, and Davis, California. Results • Well-described links between inflammation and MDD and bipolar disorder have been established. Similarly, a highly inflammatory state is a contributing factor to many significant health complications, and omega-3 PUFAs can help treat those issues. Conclusions • The research team concluded that omega-3 fatty acids have therapeutic benefits in the treatment of both MDD and bipolar disorder and are effective as a monotherapy and, particularly, as an adjunct therapy. The efficacy of omega-3 supplementation is clearly useful in promoting better health overall and supplementation should be encouraged in the primary care setting. A meta-analysis exploring an adjunct treatment of supplemental eicosapentaenoic acid or docosahexaenoic acid is likely to yield the greatest benefits to psychiatric conditions and provide an answer to proper dosing regimens. The team also created a chart of the supplements' salient features, demonstrating the overall health benefits of omega-3 fatty acids.
背景 • 心理神经免疫学是一门跨学科研究，它将行为健康与神经内分泌系统联系起来，并研究这种联系对人类免疫系统的双向影响。机制研究表明，ω-3多不饱和脂肪酸（PUFA），如鱼油中所含的那些脂肪酸，如何调节参与炎症、交感神经活动、氧化应激、转录因子和炎性细胞因子产生的关键途径。
目的 • 研究团队旨在研究PUFA对大脑和免疫系统的影响，包括促炎细胞因子和氧化应激的影响，以及它们在重度抑郁症（MDD）和双相情感障碍中作为替代单一疗法或辅助补充治疗的治疗益处。
设计 • 通过PubMed和谷歌学术进行文献检索，对出版日期和地理位置均无限制。
地点 • 研究在华盛顿特区和加利福尼亚州戴维斯的研究机构进行。
结果 • 炎症与MDD和双相情感障碍之间已建立了详尽描述的联系。同样，高度炎症状态是许多重大健康并发症的一个促成因素，而ω-3多不饱和脂肪酸有助于治疗这些问题。
结论 • 研究团队得出结论，ω-3脂肪酸在治疗MDD和双相情感障碍方面具有治疗益处，作为单一疗法有效，特别是作为辅助疗法。补充ω-3脂肪酸的功效显然有助于整体促进更好的健康，应在初级保健环境中鼓励补充。一项探索补充二十碳五烯酸或二十二碳六烯酸作为辅助治疗的荟萃分析可能会给精神疾病带来最大益处，并为适当的给药方案提供答案。该团队还创建了一份补充剂显著特征图表，展示了ω-3脂肪酸对整体健康的益处。
