Weis Serge, Büttner Andreas
Division of Neuropathology, Department of Pathology and Neuropathology, Kepler University Hospital and School of Medicine, Johannes Kepler University, Linz, Austria.
Department of Forensic Medicine, University of Rostock, Rostock, Germany.
Handb Clin Neurol. 2017;145:175-180. doi: 10.1016/B978-0-12-802395-2.00013-4.
Alcohol abuse and dependence are serious medical and economic problems in Western countries. Brain changes encountered in alcoholism are manifold and encompass brain atrophy, selective neuronal loss, astroglial, and microglial changes. Alcohol-related disorders are complex multifactorial disorders where the interaction of multiple genes and environment plays an important role in the pathogenesis.
在西方国家，酒精滥用和酒精依赖是严重的医学和经济问题。酒精中毒时出现的大脑变化是多方面的，包括脑萎缩、选择性神经元丧失、星形胶质细胞和小胶质细胞变化。酒精相关障碍是复杂的多因素障碍，其中多个基因与环境的相互作用在发病机制中起重要作用。
