Adle-Biassette Homa, Golden Jeffery A, Harding Brian
Department of Pathology, Lariboisière Hospital, APHP and Paris Diderot University, Sorbonne Paris Cité, Paris, France.
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Handb Clin Neurol. 2017;145:51-78. doi: 10.1016/B978-0-12-802395-2.00006-7.
This chapter briefly describes the normal development of the nervous system, the neuropathology and pathophysiology of acquired and secondary disorders affecting the embryo, fetus, and child. They include CNS manifestations of chromosomal change; forebrain patterning defects; disorders of the brain size; cell migration and specification disorders; cerebellum, hindbrain and spinal patterning defects; hydrocephalus; secondary malformations and destructive pathologies; vascular malformations; arachnoid cysts and infectious diseases. The distinction between malformations and disruptions is important for pathogenesis and genetic counseling.
本章简要描述了神经系统的正常发育，以及影响胚胎、胎儿和儿童的后天性和继发性疾病的神经病理学和病理生理学。它们包括染色体变化的中枢神经系统表现；前脑模式形成缺陷；脑大小异常；细胞迁移和分化异常；小脑、后脑和脊髓模式形成缺陷；脑积水；继发性畸形和破坏性病变；血管畸形；蛛网膜囊肿和传染病。畸形与破坏之间的区别对于发病机制和遗传咨询很重要。
