Division of Gastroenterology and Hepatology, Mayo Clinic, 200 1st Street Southwest, Rochester, MN 55901, USA.
Division of Gastroenterology and Hepatology, Mayo Clinic, 200 1st Street Southwest, Rochester, MN 55901, USA.
Clin Liver Dis. 2017 Nov;21(4):725-737. doi: 10.1016/j.cld.2017.06.004. Epub 2017 Jul 25.
Primary sclerosing cholangitis (PSC) is a chronic, idiopathic biliary tract disease characterized by segmental strictures. The disease is progressive with no proven treatments and may eventually lead to cirrhosis and end-stage liver disease. Abrupt changes in liver biochemistries, pain, and/or cholangitis may suggest a dominant stricture amenable to endoscopic therapy or the development of cholangiocarcinoma. Patients with PSC are at increased risk of cholangiocarcinoma. There is a strong association with inflammatory bowel disease, and an associated increased risk of colorectal cancer. Colonoscopy every 1 to 2 years is appropriate.
原发性硬化性胆管炎 (PSC) 是一种慢性、特发性胆道疾病，其特征为节段性狭窄。该疾病呈进行性发展，目前尚无明确的治疗方法，最终可能导致肝硬化和终末期肝病。肝生化指标、疼痛和/或胆管炎的突然变化可能提示存在适合内镜治疗的优势狭窄或胆管癌的发生。PSC 患者发生胆管癌的风险增加。该疾病与炎症性肠病密切相关，结直肠癌的发病风险也相应增加。因此，每 1 至 2 年进行一次结肠镜检查是合适的。
