Antenne médicale Saint-Astier, centre médical des armées de Bordeaux-Mérignac, Caserne général Dupuy, route de Gravelle, 24110 Saint-Astier, France.
Centre d'épidémiologie et de Santé publique des Armées, camp de Sainte-Marthe, 408, rue Jean-Queillau, 13014 Marseille, France.
Med Mal Infect. 2017 Dec;47(8):540-545. doi: 10.1016/j.medmal.2017.09.009. Epub 2017 Oct 4.
To determine the risk factors for severe infectious mononucleosis (IM) occurrence in immunocompetent adults.
We performed a multicenter, retrospective case series including immunocompetent adults presenting with confirmed IM between 2001 and 2011. Severe presentations were compared with uncomplicated presentations using Stata 9 software. The significance level was set at 5%.
In univariate analysis, age over 30 years (n=13 or 41.9% vs. n=5 or 12.8%; P=0.006), prior use of non-steroidal anti-inflammatory drugs (NSAIDs) (n=7 or 87.5% vs. n=1 or 12.5%; P=0.009), and smoking (n=13 or 68.4% vs. n=6 or 31.6%; P=0.013) were associated with severe IM onset. In multivariate analysis, only age over 30 years (OR=3.55; P=0.05) and prior use of NSAIDs (OR=15; P=0.05) remained associated with severe IM onset, without reaching significance level (P=0.05).
Our study confirmed that age over 30 years is a risk factor for severe IM onset. Prior use of NSAIDs also seems to be correlated with severe presentations. This new data needs to be confirmed in a prospective study.
确定免疫功能正常的成年人发生严重传染性单核细胞增多症（IM）的危险因素。
我们进行了一项多中心、回顾性病例系列研究，纳入了 2001 年至 2011 年间确诊为 IM 的免疫功能正常的成年人。使用 Stata 9 软件将严重表现与无并发症表现进行比较。显著性水平设定为 5%。
在单因素分析中，年龄大于 30 岁（n=13，41.9% vs. n=5，12.8%；P=0.006）、既往使用非甾体抗炎药（NSAIDs）（n=7，87.5% vs. n=1，12.5%；P=0.009）和吸烟（n=13，68.4% vs. n=6，31.6%；P=0.013）与严重 IM 发病相关。在多因素分析中，仅年龄大于 30 岁（OR=3.55；P=0.05）和既往使用 NSAIDs（OR=15；P=0.05）与严重 IM 发病相关，但未达到显著性水平（P=0.05）。
本研究证实，年龄大于 30 岁是严重 IM 发病的危险因素。既往使用 NSAIDs 似乎也与严重表现相关。这一新数据需要在前瞻性研究中进一步证实。
