Saint R, Kalionis B, Lockett T J, Elizur A
CSIRO Division of Entomology, Canberra, ACT, Australia.
Nature. 1988 Jul 14;334(6178):151-4. doi: 10.1038/334151a0.
Homoeo-box genes play a central role in the regulation of embryogenesis in Drosophila melanogaster. Their widespread phylogenetic distribution, and the tissue and stage specificity of their expression in other organisms, argue that they play a general and significant role in animal development. In D. melanogaster, all homoeo-box genes characterized to date are involved in major aspects of embryogenesis. We report here the molecular characterization of a Drosophila homoeo-box gene that has no apparent involvement in early embryogenesis. The gene appears to be rough, a gene implicated in pattern formation in the developing eye. It is expressed in cells within, and posterior to, the morphogenetic furrow, the site of the primary pattern forming events in the developing retina, and also in a region of the brain of the third instar larva. We have found no genetic or molecular evidence of a role for this gene in other aspects of fly development.
同源异型框基因在黑腹果蝇胚胎发育的调控中起着核心作用。它们广泛的系统发育分布，以及在其他生物体中表达的组织和阶段特异性，表明它们在动物发育中发挥着普遍而重要的作用。在黑腹果蝇中，迄今为止鉴定出的所有同源异型框基因都参与胚胎发育的主要方面。我们在此报告一个果蝇同源异型框基因的分子特征，该基因似乎与早期胚胎发育无关。该基因似乎是粗糙基因，一个与发育中的眼睛图案形成有关的基因。它在形态发生沟内及后方的细胞中表达，形态发生沟是发育中的视网膜中主要图案形成事件的发生部位，并且在三龄幼虫大脑的一个区域中也有表达。我们没有发现该基因在果蝇发育的其他方面发挥作用的遗传或分子证据。
