Kasper S, Wehr T A, Rosenthal N E
Psychiatrische Universitätsklinik, Heidelberg.
Nervenarzt. 1988 Apr;59(4):200-14.
The efficacy of phototherapy with bright, fluorescent, full-spectrum light for treatment of seasonal affective disorders (SAD) has now been widely demonstrated in controlled studies. However, treatment with dim light did not reveal a significant therapeutic improvement. Specific parameters of light treatment are necessary or optimal for producing this response and light intensity and duration in contrast to timing and spectrum seem to be a major importance. The mechanism of action of phototherapy is closely linked to the psychobiology of SAD and has not yet been satisfactorily explained. Among the several theories which have been proposed, the melatonin hypothesis and phase shift hypothesis have been the basis for the earlier studies. Newer theories also include the function of further neuroendocrine systems, as well as neurotransmitter and immune function and electrophysiological mechanisms. Until now, the value of phototherapy in the treatment of other non-seasonal syndromes has not yet been explored thoroughly and this line of research seems worth continuing.
明亮、荧光、全光谱光疗治疗季节性情感障碍（SAD）的疗效现已在对照研究中得到广泛证实。然而，弱光治疗并未显示出显著的治疗改善效果。光疗产生这种反应需要特定参数或最佳参数，与时间和光谱相比，光强度和持续时间似乎至关重要。光疗的作用机制与SAD的心理生物学密切相关，尚未得到令人满意的解释。在提出的几种理论中，褪黑素假说和相位转移假说一直是早期研究的基础。更新的理论还包括其他神经内分泌系统的功能，以及神经递质、免疫功能和电生理机制。到目前为止，光疗在治疗其他非季节性综合征方面的价值尚未得到充分探索，这一研究方向似乎值得继续。
