Miclea J M, Baurmann H, Gessain A, Ferchal F, Villette D, Rabian C, Daniel M T, Schmidt D, Tea N, Castaigne S
Département d'Hématologie, LOI CNRS. Paris, France.
Nouv Rev Fr Hematol (1978). 1988;30(1-2):89-92.
We report a case of acute adult T-cell leukemia associated with HTLV1 infection in a young African woman. The leukemic proliferation consisted of CD4-, CD25-positive lymphoid cells with typically convoluted nuclei and monoclonal integration of the HTLV1-proviral DNA. The clinical course was characterized by a rapid progression of the leukemia with development of hypercalcemia, resistance to chemotherapy, and the presence of multiple opportunistic infections. The additional finding of a seropositivity for HIV2 raises the problem of the respective contribution of the two retroviruses in this patient's disease.
我们报告了一名年轻非洲女性患与HTLV1感染相关的急性成人T细胞白血病的病例。白血病增殖由CD4 -、CD25阳性的淋巴样细胞组成，其细胞核通常呈卷曲状，且HTLV1前病毒DNA存在单克隆整合。临床病程的特点是白血病迅速进展，伴有高钙血症、化疗耐药以及多种机会性感染。HIV2血清学阳性这一额外发现引发了两种逆转录病毒在该患者疾病中各自作用的问题。
