Liu Tiaotiao, Bai Wenwen, Xia Mi, Tian Xin
School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, 300070, China.
School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, 300070, China.
Behav Brain Res. 2018 Feb 15;338:1-8. doi: 10.1016/j.bbr.2017.10.003. Epub 2017 Oct 4.
Working memory refers to a system that is essential for performing complex cognitive tasks such as reasoning, comprehension and learning. Evidence shows that hippocampus (HPC) and prefrontal cortex (PFC) play important roles in working memory. The HPC-PFC interaction via theta-band oscillatory synchronization is critical for successful execution of working memory. However, whether one brain region is leading or lagging relative to another is still unclear. Therefore, in the present study, we simultaneously recorded local field potentials (LFPs) from rat ventral hippocampus (vHPC) and medial prefrontal cortex (mPFC) and while the rats performed a Y-maze working memory task. We then applied instantaneous amplitudes cross-correlation method to calculate the time lag between PFC and vHPC to explore the functional dynamics of the HPC-PFC interaction. Our results showed a strong lead from vHPC to mPFC preceded an animal's correct choice during the working memory task. These findings suggest the vHPC-leading interaction contributes to the successful execution of working memory.
工作记忆指的是一个对于执行复杂认知任务（如推理、理解和学习）至关重要的系统。有证据表明，海马体（HPC）和前额叶皮质（PFC）在工作记忆中发挥着重要作用。通过θ波段振荡同步实现的HPC-PFC交互对于工作记忆的成功执行至关重要。然而，一个脑区相对于另一个脑区是领先还是滞后仍不清楚。因此，在本研究中，我们在大鼠执行Y迷宫工作记忆任务时，同时记录了大鼠腹侧海马体（vHPC）和内侧前额叶皮质（mPFC）的局部场电位（LFP）。然后，我们应用瞬时振幅互相关方法来计算PFC和vHPC之间的时间延迟，以探索HPC-PFC交互的功能动态。我们的结果表明，在工作记忆任务期间，动物做出正确选择之前，vHPC对mPFC有很强的领先作用。这些发现表明，vHPC领先的交互作用有助于工作记忆的成功执行。
