"Cantacuzino" National Medical Military Institute for Research and Development, 050097 Bucharest, Romania.
Pathology Department, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Int J Environ Res Public Health. 2023 Feb 9;20(4):3025. doi: 10.3390/ijerph20043025.
The increasing radiofrequency (RF) electromagnetic radiation pollution resulting from the development and use of technologies utilizing RF has sparked debate about the possible biological effects of said radiation. Of particular concern is the potential impact on the brain, due to the close proximity of communication devices to the head. The main aim of this study was to examine the effects of long-term exposure to RF on the brains of mice in a real-life scenario simulation compared to a laboratory setting. The animals were exposed continuously for 16 weeks to RF using a household Wi-Fi router and a laboratory device with a frequency of 2.45 GHz, and were compared to a sham-exposed group. Before and after exposure, the mice underwent behavioral tests (open-field test and Y-maze); at the end of the exposure period, the brain was harvested for histopathological analysis and assessment of DNA methylation levels. Long-term exposure of mice to 2.45 GHz RF radiation increased their locomotor activity, yet did not cause significant structural or morphological changes in their brains. Global DNA methylation was lower in exposed mice compared to sham mice. Further research is needed to understand the mechanisms behind these effects and to understand the potential effects of RF radiation on brain function.
随着利用射频技术的发展和应用所导致的射频电磁辐射污染的增加，有关这种辐射可能产生的生物影响的争论也随之出现。由于通讯设备与头部的距离很近，因此特别令人关注的是其对大脑的潜在影响。本研究的主要目的是在现实生活场景模拟中，与实验室环境相比，研究长期暴露于射频对老鼠大脑的影响。使用家用 Wi-Fi 路由器和频率为 2.45GHz 的实验室设备，对动物进行了长达 16 周的连续射频暴露，并与假暴露组进行了比较。在暴露前后，对老鼠进行了行为测试（旷场测试和 Y 迷宫）；在暴露期结束时，收获大脑进行组织病理学分析和 DNA 甲基化水平评估。与假暴露组相比，2.45GHz 射频辐射长期暴露于老鼠可增加其运动活性，但不会导致大脑结构或形态发生明显变化。与假暴露组相比，暴露组的老鼠的全基因组 DNA 甲基化水平较低。需要进一步的研究来了解这些影响背后的机制，并了解射频辐射对大脑功能的潜在影响。
