左侧尾状核中额回灰质体积介导了年龄对自我启动的详尽编码策略的影响。
Left caudal middle frontal gray matter volume mediates the effect of age on self-initiated elaborative encoding strategies.
机构信息
Department of Psychology, Saint Louis University, St. Louis, MO 63108, USA.
Department of Radiology, Washington University in St. Louis, St. Louis, MO 63130, USA.
出版信息
Neuropsychologia. 2017 Nov;106:341-349. doi: 10.1016/j.neuropsychologia.2017.10.004. Epub 2017 Oct 4.
Aging is associated with decreased self-initiated use of effective elaborative encoding strategies. Little is currently known regarding what factors drive age differences in self-initiated encoding strategies. The present research investigated whether age differences in prefrontal gray matter integrity contribute to age differences in self-initiated elaborative encoding strategies. The relationships between age, prefrontal regional gray matter volumes, and overall use of self-initiated elaborative encoding strategies were examined in healthy younger and older adults. Gray matter volume was calculated from structural MRI scans using Freesurfer. Encoding strategy use was assessed by retrospective item-by-item strategy self-reports given after a verbal intentional encoding task. Left caudal middle frontal gray matter volume mediated the effect of age on overall self-initiated use of elaborative encoding strategies. This suggests that age-associated declines in prefrontal gray matter integrity significantly contribute to age-associated declines in effective encoding strategies.
衰老是与自我发起的有效详细编码策略的使用减少有关。目前对于是什么因素导致自我发起的编码策略在年龄上存在差异知之甚少。本研究调查了前额叶灰质完整性的年龄差异是否导致自我发起的详细编码策略的年龄差异。本研究在健康的年轻和老年成年人中，研究了年龄、前额叶区域灰质体积与自我发起的详细编码策略的整体使用之间的关系。使用 Freesurfer 从结构 MRI 扫描中计算灰质体积。编码策略的使用是通过在口头有意编码任务后逐项进行策略自我报告来评估的。左侧尾状核中额回灰质体积介导了年龄对整体自我发起的详细编码策略使用的影响。这表明，与年龄相关的前额叶灰质完整性下降显著导致了与年龄相关的有效编码策略的下降。
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