Bitra Anusha, Rani B Jhansi, Agarkar Sanket S, Parihar Anuj S, Vynath Gopinath P, Grover Shekhar
Department of Orthodontics and Dentofacial Orthopaedics Drs Sudha and Nageswara Rao Siddhartha Institute of Dental Sciences, Vijayawada, Andhra Pradesh, India.
Department of Orthodontics, Dr. D. Y. Patil Dental College & Hospital, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India.
J Contemp Dent Pract. 2017 Oct 1;18(10):933-936. doi: 10.5005/jp-journals-10024-2152.
Orthodontic treatment is one of the commonly used dental treatments. Orthodontic forces act on the bone by modulating the biomolecules, chiefly the osteoprotegerin (OPG), osteopontin (OPN), receptor activator of nuclear factor kappa-B (RANK), and RANK ligand (RANKL) (OPG ligand). Hormonal changes are known to cause marked alteration in the levels of these biomolecules. Hence, we planned this study to evaluate the response of bone biomarkers in the gingival crevicular fluid (GCF) in postmenopausal women undergoing fixed orthodontic therapy.
This study included assessment of 50 subjects who underwent orthodontic treatment from June 2012 to July 2016. All the patients were divided into two study groups with 25 patients in each group: premenopausal group and postmenopausal group. Similar orthodontic wires were used for controlling the forces applied in subjects of both the study groups and their GCF levels of RANKL, and OPN was assessed at baseline and 24 hours after the activation of orthodontic forces. All the results were compiled, assessed, and analyzed by Statistical Package for the Social Sciences software version 16.0. Chi-square test, Student's t-test, and Mann-Whitney U test were used for the assessment of the level of significance.
The mean values of RANKL and OPN in the premenopausal and postmenopausal groups were found to be 241.52 and 317.15 pg/μL respectively. The mean values of RANKL at baseline in the premenopausal and postmenopausal groups were found to be 7.15 and 3.84 pg/μL respectively. Nonsignificant results were obtained while comparing mean OPN and RANKL level alteration in between the two study groups.
The mean alterations in the GCF levels of bone biomarkers are similar for both premenopausal and postmeno-pausal women.
For women with either premenopausal or postmenopausal status, orthodontic treatment appears to be equally safer.
正畸治疗是常用的牙科治疗方法之一。正畸力通过调节生物分子作用于骨骼，主要是骨保护素（OPG）、骨桥蛋白（OPN）、核因子κB受体激活剂（RANK）和RANK配体（RANKL）（OPG配体）。已知激素变化会导致这些生物分子水平发生显著改变。因此，我们开展本研究以评估接受固定正畸治疗的绝经后女性龈沟液（GCF）中骨生物标志物的反应。
本研究纳入了2012年6月至2016年7月期间接受正畸治疗的50名受试者。所有患者分为两个研究组，每组25例患者：绝经前组和绝经后组。两组研究对象均使用相似的正畸弓丝来控制施加的力，并在基线以及正畸力激活后24小时评估其GCF中RANKL和OPN的水平。所有结果均通过社会科学统计软件包16.0进行汇总、评估和分析。采用卡方检验、学生t检验和曼-惠特尼U检验来评估显著性水平。
绝经前组和绝经后组中RANKL和OPN的平均值分别为241.52和317.15 pg/μL。绝经前组和绝经后组基线时RANKL的平均值分别为7.15和3.84 pg/μL。比较两组研究对象的平均OPN和RANKL水平变化时，结果无显著性差异。
绝经前和绝经后女性GCF中骨生物标志物水平的平均变化相似。
对于处于绝经前或绝经后状态的女性，正畸治疗似乎同样安全。
