Ashrafi Farzaneh, Iraj Bijan, Nematollahi Pardis, Darakhshandeh Ali
Hematologist and Medical Oncologist, Isfahan University of Medical Sciences, Isfahan, Iran.
Endocrinologist, Isfahan University of Medical Sciences, Isfahan, Iran.
Int J Hematol Oncol Stem Cell Res. 2017 Jul 1;11(3):246-249.
Hypercalcemia is a common finding in patients with multiple myeloma. Clinical manifestations of hypercalcemia correlate with the level of serum calcium. Ionized serum calcium (Ca (I)) will be increased in true hypercalcemia. In pseudohypercalcemia the Ionized Ca is normal, although binding of calcium to abnormal immunoglobulin causes increased serum calcium level. In the asymptomatic multiple myeloma patients with moderate to severe hypercalcemia, measurement of ionized calcium is critical to exclude pseudohypercalcemia. Here, we describe an asymptomatic 44-year-old man with multiple myeloma who had severe hypercalcemia, but normal serum Ionized Ca level.
高钙血症是多发性骨髓瘤患者的常见表现。高钙血症的临床表现与血清钙水平相关。在真性高钙血症中，血清离子钙（Ca (I)）会升高。在假性高钙血症中，尽管钙与异常免疫球蛋白的结合导致血清钙水平升高，但离子钙是正常的。对于无症状的中度至重度高钙血症的多发性骨髓瘤患者，测量离子钙对于排除假性高钙血症至关重要。在此，我们描述了一名44岁无症状的多发性骨髓瘤男性患者，他有严重高钙血症，但血清离子钙水平正常。
