Shi Chenyang, Teerakapibal Rattavut, Yu Lian, Zhang Geoff G Z
Drug Product Development, Research and Development, AbbVie Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, USA.
IUCrJ. 2017 Jul 10;4(Pt 5):555-559. doi: 10.1107/S2052252517009344. eCollection 2017 Sep 1.
Using high-brilliance high-energy synchrotron X-ray radiation, for the first time the total scattering of a thin organic glass film deposited on a strongly scattering inorganic substrate has been measured in transmission mode. The organic thin film was composed of the weakly scattering pharmaceutical substance indomethacin in the amorphous state. The film was 130 µm thick atop a borosilicate glass substrate of equal thickness. The atomic pair distribution function derived from the thin-film measurement is in excellent agreement with that from bulk measurements. This ability to measure the total scattering of amorphous organic thin films in transmission will enable accurate structural studies for a wide range of materials.
利用高亮度高能同步加速器X射线辐射，首次在透射模式下测量了沉积在强散射无机衬底上的有机玻璃薄膜的总散射。该有机薄膜由非晶态的弱散射药物吲哚美辛组成。该薄膜在厚度相同的硼硅酸盐玻璃衬底上，厚度为130 µm。从薄膜测量中得出的原子对分布函数与体相测量结果高度吻合。这种在透射模式下测量非晶态有机薄膜总散射的能力将使对多种材料进行精确的结构研究成为可能。
