Tang Shuo, Bhandari Rohit, Delaney Sean P, Munson Eric J, Dziubla Thomas D, Hilt J Zach
Department of Chemical and Materials Engineering, University of Kentucky, Lexington, Kentucky 40506, USA.
Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40506, USA.
Mater Today Commun. 2017 Mar;10:46-53. doi: 10.1016/j.mtcomm.2016.12.003. Epub 2016 Dec 31.
Two series of thermosensitive hydrogels were synthesized by copolymerizing N-isopropylacrylamide (NIPAAm) with various contents of novel hydrophobic crosslinkers, curcumin multiacrylate (CMA) and quercetin multiacrylate (QMA). The compositions of the resulting hydrogels were characterized using solid state-NMR (ss-NMR), and the temperature dependent swelling behavior and lower critical solution temperature (LCST) were characterized using swelling studies and differential scanning calorimetry (DSC). Increasing the crosslinker content resulted in a significant decrease in the LCST and swelling ratio of hydrogels, which could be attributed to the increased hydrophobicity introduced by CMA or QMA. All of the hydrogels demonstrated temperature responsive swelling with the extent of swelling decreasing with increasing crosslinker content. The lower crosslinker content gels displayed sharper phase transitions, while the high crosslinker content gels had broader phase transitions.
通过将N-异丙基丙烯酰胺（NIPAAm）与不同含量的新型疏水性交联剂姜黄素多丙烯酸酯（CMA）和槲皮素多丙烯酸酯（QMA）共聚，合成了两系列热敏水凝胶。使用固态核磁共振（ss-NMR）对所得水凝胶的组成进行了表征，并通过溶胀研究和差示扫描量热法（DSC）对温度依赖性溶胀行为和低临界溶液温度（LCST）进行了表征。交联剂含量的增加导致水凝胶的LCST和溶胀率显著降低，这可归因于CMA或QMA引入的疏水性增加。所有水凝胶均表现出温度响应性溶胀，溶胀程度随交联剂含量的增加而降低。较低交联剂含量的凝胶表现出更尖锐的相变，而较高交联剂含量的凝胶具有更宽的相变。
