Huang Li-Hao, Lavine Kory J, Randolph Gwendalyn J
Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, 63110 USA.
Center for Cardiovascular Research, Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110 USA.
JACC Basic Transl Sci. 2017 Aug;2(4):477-483. doi: 10.1016/j.jacbts.2017.02.005. Epub 2017 Aug 28.
The lymphatic vasculature plays a key role throughout the body in regulating tissue fluid homeostasis, lipid transport, and immune surveillance. Whereas it has been appreciated that the heart relies on lymphatic vessels to maintain fluid balance and that such balance must be tightly maintained to allow for normal cardiac output, it has only recently come to light that the lymphatic vasculature might serve as a therapeutic target to promote optimal healing following myocardial ischemia and infarction. We review the subject of cardiac lymphatic vessels herein and highlight studies that imply targeting of lymphatic vessel development or transport may serve as a promising avenue for future clinical application in the context of ischemic injury.
淋巴脉管系统在全身调节组织液稳态、脂质运输和免疫监视中发挥着关键作用。虽然人们已经认识到心脏依赖淋巴管来维持液体平衡，并且这种平衡必须严格维持以保证正常的心输出量，但直到最近才发现，淋巴脉管系统可能作为一个治疗靶点，以促进心肌缺血和梗死后的最佳愈合。我们在此回顾心脏淋巴管的相关主题，并强调一些研究，这些研究表明靶向淋巴管发育或运输可能是缺血性损伤未来临床应用的一个有前景的途径。
