Wang Ya-Chao, Meng Wan-Ting, Zhang Hai-Feng, Zhu Jing, Wang Qiang-Li, Mou Fang-Fang, Guo Hai-Dong
Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Department of Anatomy, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Department of Human Anatomy, Xuzhou Medical University, Xuzhou 221004, China.
Microvasc Res. 2023 Jan;145:104442. doi: 10.1016/j.mvr.2022.104442. Epub 2022 Oct 4.
The lymphatic vascular system is crucial for the regulation of tissue fluid homeostasis, lipid metabolism, and immune function. Cardiac injury quickly leads to myocardial edema, cardiac lymphatic dysfunction, which ultimately results in myocardial fluid imbalance and cardiac dysfunction. Therefore, lymphangiogenesis-targeted therapy may improve the recovery of myocardial function post cardiac ischemia as observed in myocardial infarction (MI). Indeed, a promising strategy for the clinical treatment of MI relies on vascular endothelial growth factor-C (VEGF-C)-targeted therapy, which promotes lymphangiogenesis. However, much effort is needed to identify the mechanisms of lymphatic transport in response to heart disease. This article reviews regulatory factors of lymphangiogenesis, and discusses the effects of lymphangiogenesis on cardiac function after cardiac injury and its regulatory mechanisms. The involvement of stem cells on lymphangiogenesis was also discussed as stem cells could differentiate into lymphatic endothelial cells (LECs) and stimulate phenotype of LECs.
淋巴血管系统对于调节组织液稳态、脂质代谢和免疫功能至关重要。心脏损伤会迅速导致心肌水肿、心脏淋巴功能障碍，最终导致心肌液失衡和心脏功能障碍。因此，如在心肌梗死（MI）中观察到的那样，靶向淋巴管生成的治疗可能会改善心脏缺血后心肌功能的恢复。事实上，MI临床治疗的一个有前景的策略依赖于靶向血管内皮生长因子-C（VEGF-C）的治疗，该治疗可促进淋巴管生成。然而，需要付出很多努力来确定响应心脏病的淋巴运输机制。本文综述了淋巴管生成的调节因子，并讨论了心脏损伤后淋巴管生成对心脏功能的影响及其调节机制。还讨论了干细胞对淋巴管生成的参与，因为干细胞可以分化为淋巴管内皮细胞（LEC）并刺激LEC的表型。
