Banovic Frane, Jerry Carmen, Howerth Elizabeth
Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, 2200 College Station Road, Athens, GA, 30602, USA.
Department of Pathology, College of Veterinary Medicine, University of Georgia, 2200 College Station Road, Athens, GA, 30602, USA.
Vet Dermatol. 2018 Feb;29(1):85-e35. doi: 10.1111/vde.12502. Epub 2017 Oct 8.
Dermal arteritis of the nasal philtrum is a rarely reported condition commonly affecting large breed dogs.
To describe the effective treatment of nasal philtrum arteritis with topical tacrolimus in one dog.
A 9-year-old, intact male German shorthair pointer dog was presented with well-demarcated deep erythematous ulcers targeting exclusively the skin of the nasal philtrum, accompanied by frequent series of haemorrhage.
Complete blood count, serum chemistry profile, urinalysis, histopathological examination and immunohistochemistry of skin biopsies.
The presence of a V-shaped ulcer with subendothelial spindle cell proliferation resulting in stenosis of dermal arteries and arterioles on histological evaluation, together with a well-demarcated deep nasal philtrum ulcer was consistent with arteritis of the nasal philtrum. Treatment was initiated with twice daily oral doxycycline and niacinamide in conjunction with topical fluocinolone cream. Over the course of two years, the lesions progressed with frequent bleeding episodes. A novel surgical approach provided deep resection of all grossly affected tissue; four months later a recurrence of fissures and occasional mild bleeding from the original site was noted and there was no improvement after another two months of oral doxycycline/niacinamide and topical fluocinolone treatment. Topical application of 0.1% tacrolimus twice daily resulted in complete healing of the ulceration and normalization of the epidermis. Over the subsequent 15 months, the dog's lesions remained in remission with topical tacrolimus application twice daily.
Topical tacrolimus ointment appeared effective at inducing and maintaining lesion remission in this dog with nasal philtrum arteritis.
鼻唇沟皮肤动脉炎是一种罕见的疾病，常见于大型犬。
描述一只犬鼻唇沟动脉炎局部应用他克莫司的有效治疗方法。
一只9岁未绝育的雄性德国短毛指示犬，其鼻唇沟皮肤出现界限清晰的深部红斑性溃疡，伴有频繁出血。
进行全血细胞计数、血清生化检查、尿液分析、皮肤活检的组织病理学检查和免疫组化。
组织学评估显示存在V形溃疡，内皮下梭形细胞增生导致真皮动脉和小动脉狭窄，同时鼻唇沟深部界限清晰的溃疡与鼻唇沟动脉炎相符。治疗开始时口服强力霉素和烟酰胺，每日两次，同时外用氟轻松乳膏。在两年的病程中，病变进展并频繁出血。一种新的手术方法对所有肉眼可见的病变组织进行了深部切除；四个月后，原部位出现裂隙复发并偶尔有轻度出血，口服强力霉素/烟酰胺和外用氟轻松治疗两个月后无改善。每日两次局部应用0.1%他克莫司导致溃疡完全愈合，表皮恢复正常。在随后的15个月里，该犬每日两次局部应用他克莫司，病变一直处于缓解状态。
局部应用他克莫司软膏似乎能有效诱导和维持这只患有鼻唇沟动脉炎犬的病变缓解。
