Institute of Molecular Biology, Johannes Gutenberg-University, Jacob Welder Weg 26, 55128, Mainz, Germany.
Institute of Inorganic Chemistry, Christian Alberts University Kiel, Max Eyth Strasse 2, 24118, Kiel, Germany.
Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14352-14354. doi: 10.1002/anie.201708214. Epub 2017 Oct 9.
Show your metal: l-Tyrosine is converted into the protective antioxidative polymer melanin in a sequence of reactions. In humans, the catalytic pathway starts with the tyrosinase HsTYR and two tyrosinase-related proteins HsTYRP1 and HsTYRP2. All three enzymes have the same active site but the latter two contain two zinc ions instead of copper ions.
l-酪氨酸在一系列反应中转化为具有保护作用的抗氧化聚合物黑色素。在人类中，催化途径始于酪氨酸酶 HsTYR 和两种酪氨酸酶相关蛋白 HsTYRP1 和 HsTYRP2。这三种酶具有相同的活性位点，但后两种酶含有两个锌离子而不是铜离子。
