Chepchirchir Angeline, Jaoko Walter, Nyagol Joshua
a School of Nursing Sciences , University of Nairobi-Kenya , Nairobi , Kenya.
b Institute of Tropical and Infectious Diseases , University of Nairobi-Kenya , Nairobi , Kenya.
AIDS Care. 2018 May;30(5):544-550. doi: 10.1080/09540121.2017.1384533. Epub 2017 Oct 9.
There is paucity of data on prevalence of hypertension and its effects on HIV/AIDS progression among patients at Kenyatta National Hospital (KNH), Kenya. This was a cross sectional study conducted between January and May 2015 at the KNH HIV Care Centre. Ethical approval was obtained from institutional ethics review board. HIV positive adult patients were recruited sequentially, and written informed consent obtained from each participant. Systematic sampling was used to select participants who were screened for blood pressure, body mass index (BMI) and lifestyle characteristics. Data on clinical parameters were extracted from patient records. A total of 297 participants (89 males and 208 females) were enrolled in the study. The participants were socially diverse in cultural beliefs, religious practices and lifestyles. Their ages ranged from 30 to 57 years, and the average age of males (M = 44.56, SD = 6.05) was higher than females (M = 42.29, SD = 6.16), p < .01. The prevalence of hypertension was found to be 23.2%. The relation between CD4 counts and creatinine was statistically significant, p < .01, as was the association between CD4 counts and BMI, p < .01. Hypertension is a highly prevalent co-morbidity in HIV patients. The risk factors include prolonged use of ART as well as increased body mass index. The effects of hypertension on HIV progression include low CD4+ T cell counts which complicate the underlying immunosuppression.
关于肯尼亚肯雅塔国家医院（KNH）患者中高血压患病率及其对艾滋病毒/艾滋病进展影响的数据匮乏。这是一项于2015年1月至5月在KNH艾滋病毒护理中心进行的横断面研究。已获得机构伦理审查委员会的伦理批准。艾滋病毒阳性成年患者按顺序招募，并获得每位参与者的书面知情同意书。采用系统抽样方法选择接受血压、体重指数（BMI）和生活方式特征筛查的参与者。临床参数数据从患者记录中提取。共有297名参与者（89名男性和208名女性）纳入研究。参与者在文化信仰、宗教习俗和生活方式方面具有社会多样性。他们的年龄在30至57岁之间，男性的平均年龄（M = 44.56，标准差 = 6.05）高于女性（M = 42.29，标准差 = 6.16），p <.01。高血压患病率为23.2%。CD4细胞计数与肌酐之间的关系具有统计学意义，p <.01，CD4细胞计数与BMI之间的关联也具有统计学意义，p <.01。高血压是艾滋病毒患者中一种高度普遍的合并症。危险因素包括长期使用抗逆转录病毒疗法以及体重指数增加。高血压对艾滋病毒进展的影响包括CD4 + T细胞计数低，这使潜在的免疫抑制情况复杂化。
