Zhang Xianhui, Wang Wei, Li Yuanjun, Wang Hui, Liu Runtao, Zhu Lei
1 Department of Laboratory Medicine, Children's Hospital of Shanxi Province, Tai'yuan, China.
2 Department of Laboratory Medicine, Shanxi Provincial People's Hospital, Taiyuan, China.
Clin Pediatr (Phila). 2018 Jun;57(7):802-805. doi: 10.1177/0009922817734362. Epub 2017 Oct 9.
Vitamin D can play a vital role in autoimmune diseases. Epidemiologic evidence demonstrates vitamin D deficiency excited in adult patients with vitiligo.
To investigate 25-hydroxyvitamin D (25(OH)D) levels in children with vitiligo and explore possible relevant factors.
A total of 114 patients and 100 controls were included in our case-control study. We analyzed the required data collected by the questionnaire and examination to reveal the correlation with 25(OH)D levels.
The mean serum 25(OH)D levels in patients and controls were 43.62 ± 19.23 and 67.87 ± 19.45 nmol/L, respectively. The rate of deficient in patients and controls are 14.9% and 2%, respectively. There was significant difference between the 2 groups. Significant differences also existed on different ages comparing serum vitamin D levels of patients with controls ( P < .001). Age was an independent factor affecting 25(OH)D level ( P = .032). Two (1.8%) and 4 (3.5%) of children with vitiligo have comorbid autoimmune diseases and family history, respectively. There was no correlation between sex, duration of disease, type of vitiligo, skin lesion location, stage, family history, and comorbid autoimmune diseases with 25(OH)D levels.
Serum vitamin D level was associated with onset vitiligo children. More sunshine and vitamin D fortified foods are necessary among children with age. The rates of children vitiligo with family history has decreased in China.
维生素D在自身免疫性疾病中可发挥重要作用。流行病学证据表明成年白癜风患者中存在维生素D缺乏现象。
研究白癜风患儿的25-羟基维生素D（25(OH)D）水平，并探讨可能的相关因素。
我们的病例对照研究共纳入114例患者和100例对照。我们分析了通过问卷调查和检查收集的所需数据，以揭示与25(OH)D水平的相关性。
患者和对照的血清25(OH)D平均水平分别为43.62±19.23和67.87±19.45 nmol/L。患者和对照的缺乏率分别为14.9%和2%。两组之间存在显著差异。在不同年龄组中，比较患者和对照的血清维生素D水平也存在显著差异（P<.001）。年龄是影响25(OH)D水平的独立因素（P=.032）。白癜风患儿中分别有2例（1.8%）和4例（3.5%）患有合并自身免疫性疾病和家族史。性别、病程、白癜风类型、皮肤病变部位、分期、家族史和合并自身免疫性疾病与25(OH)D水平之间无相关性。
血清维生素D水平与白癜风患儿的发病有关。对于不同年龄段的儿童，需要更多的阳光照射和富含维生素D的食物。中国白癜风患儿有家族史的比例有所下降。
