Turk J Med Sci. 2015;45(4):837-41.
BACKGROUND/AIM: Reduced vitamin D is considered as one of the environmental factors that can increase the prevalence of certain autoimmune diseases. This study aimed to assess vitamin D metabolism in patients with vitiligo.
A prospective case-control study was conducted on 44 consecutive patients with vitiligo vulgaris and 43 healthy controls. Their plasma 25-hydroxyvitamin D (25(OH)D), parathormone (PTH), calcium, magnesium, and phosphate levels were measured.
There was no significant difference in the mean age, sex and Fitzpatrick skin phototype between the patient and control groups (P > 0.05). The plasma levels of 25(OH)D and calcium were significantly decreased (P = 0.002, P < 0.0001, respectively) and PTH and magnesium levels were significantly increased in patients with vitiligo (P < 0.0001, P < 0.0001, respectively). The advancement of age (P = 0.03, R = -0.18) and comorbid autoimmune illnesses (P = 0.04) were found to be significantly associated with lower 25(OH)D levels.
There is a universal lack of 25(OH)D in the Turkish population. Screening for vitamin D may be a tool for the presence of comorbid autoimmune diseases. Further studies are needed to understand the role of vitamin D metabolism in the pathogenesis of vitiligo.
背景/目的：维生素 D 水平降低被认为是增加某些自身免疫性疾病患病率的环境因素之一。本研究旨在评估白癜风患者的维生素 D 代谢情况。
对 44 例寻常型白癜风患者和 43 名健康对照者进行前瞻性病例对照研究。测量其血浆 25-羟维生素 D（25(OH)D）、甲状旁腺素（PTH）、钙、镁和磷水平。
患者组和对照组在平均年龄、性别和 Fitzpatrick 皮肤光型方面无显著差异（P > 0.05）。白癜风患者的血浆 25(OH)D 和钙水平显著降低（P = 0.002，P < 0.0001），PTH 和镁水平显著升高（P < 0.0001，P < 0.0001）。年龄增长（P = 0.03，R = -0.18）和合并自身免疫性疾病（P = 0.04）与 25(OH)D 水平降低显著相关。
土耳其人群普遍缺乏 25(OH)D。筛查维生素 D 可能是发现合并自身免疫性疾病的一种手段。需要进一步研究以了解维生素 D 代谢在白癜风发病机制中的作用。
