School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong.
School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, 518060 Shenzhen 518060, China.
Curr Med Chem. 2018;25(38):5191-5217. doi: 10.2174/0929867324666171009100900.
Inflammatory bowel disease (IBD) is an uncontrolled chronic inflammatory intestinal disorder, which requires medications for long-term therapy. Facing the challenges of severe side effects and drug resistance of conventional medications, to develop the strategies meet the stringent safety and effectiveness in the long-term treatment are urgent in the clinics. In this regard, a growing body of evidence confirms plant-sourced phenols, such as flavonoids, catechins, stilbenes, coumarins, quinones, lignans, phenylethanoids, cannabinoid phenols, tannins, phenolic acids and hydroxyphenols, exert potent protective benefits with fewer undesirable effects in conditions of acute or chronic intestinal inflammation through improvement of colonic oxidative and pro-inflammatory status, preservation of the epithelial barrier function and modulation of gut microbiota. In this review, the great potential of plant-sourced phenols and their action mechanisms for the treatment or prevention of IBD in recent research are summarized, which may help further development of new preventive/adjuvant regimens for IBD.
炎症性肠病（IBD）是一种无法控制的慢性炎症性肠道疾病，需要长期药物治疗。面对传统药物严重副作用和耐药性的挑战，开发满足长期治疗严格安全性和有效性的策略在临床上非常紧迫。在这方面，越来越多的证据证实植物源酚类物质，如类黄酮、儿茶素、白藜芦醇、香豆素、醌类、木脂素、苯乙醇类、大麻素酚类、单宁、酚酸和羟基酚类，通过改善结肠氧化和促炎状态、保护上皮屏障功能和调节肠道微生物群，在急性或慢性肠道炎症中发挥强大的保护作用，副作用较少。在这篇综述中，总结了植物源酚类物质在治疗或预防 IBD 方面的巨大潜力及其作用机制，这可能有助于进一步开发新的预防/辅助 IBD 治疗方案。
