The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Nat Rev Immunol. 2018 Feb;18(2):134-147. doi: 10.1038/nri.2017.105. Epub 2017 Oct 9.
Neutrophils are innate immune phagocytes that have a central role in immune defence. Our understanding of the role of neutrophils in pathogen clearance, immune regulation and disease pathology has advanced dramatically in recent years. Web-like chromatin structures known as neutrophil extracellular traps (NETs) have been at the forefront of this renewed interest in neutrophil biology. The identification of molecules that modulate the release of NETs has helped to refine our view of the role of NETs in immune protection, inflammatory and autoimmune diseases and cancer. Here, I discuss the key findings and concepts that have thus far shaped the field of NET biology.
中性粒细胞是先天免疫吞噬细胞，在免疫防御中起着核心作用。近年来，我们对中性粒细胞在清除病原体、免疫调节和疾病发病机制中的作用的理解有了显著的提高。网状染色质结构，称为中性粒细胞胞外陷阱（NETs），一直是重新关注中性粒细胞生物学的前沿领域。鉴定调节 NETs 释放的分子有助于完善我们对 NETs 在免疫保护、炎症和自身免疫性疾病以及癌症中的作用的认识。在这里，我讨论了迄今为止塑造 NET 生物学领域的关键发现和概念。
