An Zhenyu, Zhao Lianbiao, Wu Mingzhong, Ni Jixiang, Qi Zhenjie, Yu Guiqin, Yan Rulong
State Key Laboratory of Applied Organic Chemistry, Key laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Department of Chemistry, Lanzhou University, Lanzhou, Gansu, China.
Chem Commun (Camb). 2017 Oct 19;53(84):11572-11575. doi: 10.1039/c7cc07089f.
A straightforward Fe-catalyzed method for the synthesis of pyrrolo[1,2-a]quinoxalines from 1-(2-aminophenyl)pyrroles and cyclic ethers, which includes functionalization of C(sp)-H bonds and the construction of C-C and C-N bonds, has been developed. The features of this reaction are Fe catalysis, low-cost and readily accessible starting materials. Moreover, this procedure exhibits good functional group tolerance and a series of pyrrolo[1,2-a]quinoxaline derivatives are obtained in moderate to good yields.
已开发出一种直接的铁催化方法，用于从1-(2-氨基苯基)吡咯和环醚合成吡咯并[1,2-a]喹喔啉，该方法包括C(sp)-H键的官能化以及C-C键和C-N键的构建。该反应的特点是铁催化、起始原料成本低且易于获得。此外，该方法具有良好的官能团耐受性，可中等至良好的产率得到一系列吡咯并[1,2-a]喹喔啉衍生物。
