Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Hospital Albrechtsen Research Centre, Canada.
Food Funct. 2017 Nov 15;8(11):4089-4099. doi: 10.1039/c7fo00709d.
Cyanidin 3-0-glucoside (CG) is a polyphenol with potential health benefits. In this study, we investigated, for the first time, the cardioprotective effects of CG in an animal model of myocardial infarction (MI), a major cause of death worldwide. Sham and MI rats were administered CG (10 mg kg day) daily for one week prior to surgery, and 8 weeks post-surgery. Echocardiography was performed to assess cardiac structure and function at 4 and 8 weeks. At 4 weeks, MI rats had significantly lower body mass when compared to control rats, and CG administration significantly prevented this decrease. Four-week MI rats also showed significantly increased left ventricle dilation, end systolic and end diastolic volumes in comparison to controls, and CG significantly prevented these adverse changes. Ejection fraction was significantly lower in 4-week MI rats in comparison to controls, and CG had no effect on this parameter. At 8 weeks, body mass was significantly lower in MI rats when compared to control rats, and CG significantly prevented this decrease. At 8 weeks, MI rats showed a significant increase in left ventricle dilation and isovolumic relaxation time, while ejection fraction was significantly lower when compared to controls; these parameters were not altered by CG treatment. Eight-week MI rats had significantly higher level of oxidative stress in heart tissue in comparison to controls, and CG administration did not prevent this increase. In conclusion, administration of CG was able to significantly preserve body mass in both 4 and 8 weeks MI rats, as well as significantly prevent cardiac dilation in 4 weeks MI rats. However, CG was unable to sustain this cardioprotection, as cardiac structure and function were not significantly improved in 8 weeks MI rats.
矢车菊素-3-O-葡萄糖苷（CG）是一种具有潜在健康益处的多酚。在这项研究中，我们首次研究了 CG 在心肌梗死（MI）动物模型中的心脏保护作用，MI 是全球主要的死亡原因。假手术和 MI 大鼠在术前一周和术后 8 周每天给予 CG（10mgkgday）。在 4 周和 8 周时进行超声心动图检查以评估心脏结构和功能。在 4 周时，与对照组相比，MI 大鼠的体重明显降低，而 CG 给药可显著预防这种降低。与对照组相比，4 周 MI 大鼠的左心室扩张、收缩末期和舒张末期容积明显增加，而 CG 可显著预防这些不良变化。与对照组相比，4 周 MI 大鼠的射血分数明显降低，而 CG 对该参数无影响。在 8 周时，与对照组相比，MI 大鼠的体重明显降低，而 CG 可显著预防这种降低。在 8 周时，MI 大鼠的左心室扩张和等容舒张时间明显增加，而射血分数明显低于对照组；CG 治疗并未改变这些参数。与对照组相比，8 周 MI 大鼠心脏组织的氧化应激水平明显升高，而 CG 给药并不能预防这种增加。总之，CG 给药可显著维持 4 周和 8 周 MI 大鼠的体重，并可显著预防 4 周 MI 大鼠的心脏扩张。然而，CG 不能维持这种心脏保护作用，因为 8 周 MI 大鼠的心脏结构和功能没有得到显著改善。
