Si Lislivia Yiang-Nee, Ali Siti Aishah Mohd, Latip Jalifah, Fauzi Norsyahida Mohd, Budin Siti Balkis, Zainalabidin Satirah
Program of Biomedical Science, School of Diagnostic and Applied Health Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.
School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600, Bangi, Selangor, Malaysia.
Life Sci. 2017 Dec 15;191:157-165. doi: 10.1016/j.lfs.2017.10.030. Epub 2017 Oct 21.
Obesity increase the risks of hypertension and myocardial infarction (MI) mediated by oxidative stress. This study was undertaken to investigate the actions of roselle aqueous extract (R) on cardiotoxicity in obese (OB) rats and thereon OB rats subjected to MI.
Male Sprague-Dawley rats were fed with either normal diet or high-fat diet for 8weeks. Firstly, OB rats were divided into (1) OB and (2) OB+R (100mg/kg, p.o, 28days). Then, OB rats were subjected to MI (ISO, 85mg/kg, s.c, 2days) and divided into three groups: (1) OB+MI, (2) OB+MI+R and (3) OB+MI+enalapril for another 4weeks.
Roselle ameliorated OB and OB+MI's cardiac systolic dysfunction and reduced cardiac hypertrophy and fibrosis. The increased oxidative markers and decreased antioxidant enzymes in OB and OB+MI groups were all attenuated by roselle.
These observations indicate the protective effect of roselle on cardiac dysfunction in OB and OB+MI rats, which suggest its potential to be developed as a nutraceutical product for obese and obese patients with MI in the future.
肥胖会增加由氧化应激介导的高血压和心肌梗死（MI）风险。本研究旨在探讨玫瑰茄水提取物（R）对肥胖（OB）大鼠心脏毒性的作用以及对MI后OB大鼠的影响。
雄性Sprague-Dawley大鼠分别给予正常饮食或高脂饮食8周。首先，将OB大鼠分为（1）OB组和（2）OB+R组（100mg/kg，口服，28天）。然后，对OB大鼠进行MI（异丙肾上腺素，85mg/kg，皮下注射，2天），并分为三组：（1）OB+MI组，（2）OB+MI+R组和（3）OB+MI+依那普利组，再持续4周。
玫瑰茄改善了OB和OB+MI大鼠的心脏收缩功能障碍，减轻了心脏肥大和纤维化。玫瑰茄减轻了OB组和OB+MI组中氧化标志物的增加和抗氧化酶的减少。
这些观察结果表明玫瑰茄对OB和OB+MI大鼠心脏功能障碍具有保护作用，这表明其未来有可能被开发成为肥胖及肥胖合并MI患者的营养保健品。
