通过寡核苷酸序列的脂质修饰控制G-四链体的形成。

Controlling G-quadruplex formation via lipid modification of oligonucleotide sequences.

作者信息

Vialet Brune, Gissot Arnaud, Delzor Romain, Barthélémy Philippe

机构信息

Univ. Bordeaux, ARNA Laboratory, F-33000 Bordeaux, France.

出版信息

Chem Commun (Camb). 2017 Oct 19;53(84):11560-11563. doi: 10.1039/c7cc05693a.

DOI:10.1039/c7cc05693a

PMID:28990612

Abstract

G-quadruplexes (G4) represent attractive supramolecular scaffolds. In this communication, we show that the lipid modification of a G4 prone oligonucleotide sequence drastically increases the probability of forming tetramolecular parallel G4s with unprecedented conformational control over other unspecific oligomers or folds.

摘要

G-四链体（G4）是极具吸引力的超分子支架。在本通讯中，我们表明对易于形成G4的寡核苷酸序列进行脂质修饰，极大地增加了形成四分子平行G4的概率，且对其他非特异性寡聚物或折叠具有前所未有的构象控制。