Department of Biochemistry and Molecular Biology; Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI, USA.
Wiley Interdiscip Rev Syst Biol Med. 2018 Mar;10(2). doi: 10.1002/wsbm.1406. Epub 2017 Oct 9.
Metabolic changes accompany tumor progression and metastatic dissemination of cancer cells. Yet, until recently, metabolism has received little attention in the study of cancer metastasis. Cancer cells undergo significant metabolic rewiring as they acquire metastatic traits and adapt to survive in multiple environments with varying nutrient availability, oxygen concentrations, and extracellular signals. Therefore, to effectively treat metastatic cancer, it is important to understand the metabolic strategies adopted by cancer cells during the metastatic process. Here, we focus on the metabolic pathways known to play a role in cancer metastasis, including glycolysis, the pentose phosphate pathway, tricarboxylic acid cycle, oxidative phosphorylation, amino acid metabolism, and fatty acid metabolism. Recent studies have uncovered roles for these pathways in cellular events that promote metastasis, including reactive oxygen species-mediated signaling, epigenetic regulation, and interaction with the extracellular matrix. We also discuss the metabolic interplay between immune cells and cancer cells supporting metastasis. Finally, we highlight the current limitations of our knowledge on this topic, and present future directions for the field. WIREs Syst Biol Med 2018, 10:e1406. doi: 10.1002/wsbm.1406 This article is categorized under: Biological Mechanisms > Metabolism.
代谢变化伴随着肿瘤的进展和癌细胞的转移扩散。然而，直到最近，代谢才在癌症转移的研究中受到关注。癌细胞在获得转移特性并适应在具有不同营养可用性、氧浓度和细胞外信号的多种环境中生存时，会经历显著的代谢重编程。因此，为了有效地治疗转移性癌症，了解癌细胞在转移过程中采用的代谢策略非常重要。在这里，我们专注于已知在癌症转移中发挥作用的代谢途径，包括糖酵解、磷酸戊糖途径、三羧酸循环、氧化磷酸化、氨基酸代谢和脂肪酸代谢。最近的研究揭示了这些途径在促进转移的细胞事件中的作用，包括活性氧介导的信号转导、表观遗传调控以及与细胞外基质的相互作用。我们还讨论了支持转移的免疫细胞和癌细胞之间的代谢相互作用。最后，我们强调了目前我们对这一主题的认识的局限性，并提出了该领域的未来发展方向。WIREs 系统生物学和医学 2018, 10:e1406. doi: 10.1002/wsbm.1406 本文归类于： 生物学机制 > 代谢。
