从茯苓水煎液中分离得到一种新的高氧化孕甾烷及两种新的5-羟甲基糠醛衍生物。
A new highly oxygenated pregnane and two new 5-hydroxymethylfurfural derivatives from the water decoction of Poria cocos.
作者信息
Chen Ting, Kan Yong-Jun, Chou Gui-Xin, Zhang Cheng-Gang
机构信息
a The MOE Key Laboratory of Standardization of Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica , Shanghai University of Traditional Chinese Medicine , Shanghai 201203 , China.
b Shanghai R&D Center for Standardization of Chinese Medicines , Shanghai 201203 , China.
出版信息
J Asian Nat Prod Res. 2018 Dec;20(12):1101-1107. doi: 10.1080/10286020.2017.1383398. Epub 2017 Oct 9.
A new highly oxygenated pregnane steroid, pregn-7-ene-2β,3α,15α,20-tetrol (1) and two new 5-hydroxymethylfurfural derivatives, (5-formylfuran-2-yl)methyl 2-hydroxypropanoate (2) and (5-formylfuran-2-yl)methyl 2-(4-hydroxyphenyl)acetate (3), together with four known compounds, were isolated from the water decoction of Poria cocos. Their structures were established on the basis of extensive spectroscopic analysis. Compound 1 showed moderate inhibitory activity and a known compound (3S,6S)-3-[(1R)-1-hydroxyethyl]-6-(phenylmethyl)-2,5-piperazinedione (5) showed weak inhibitory activity against α-glucosidase, respectively.
从茯苓水煎液中分离得到一种新的高度氧化孕甾烷甾体化合物孕甾-7-烯-2β,3α,15α,20-四醇（1）、两种新的5-羟甲基糠醛衍生物（5-甲酰基呋喃-2-基）甲基2-羟基丙酸酯（2）和（5-甲酰基呋喃-2-基）甲基2-（4-羟基苯基）乙酸酯（3）以及四种已知化合物。通过广泛的光谱分析确定了它们的结构。化合物1表现出中等抑制活性，一种已知化合物（3S,6S）-3-[(1R)-1-羟乙基]-6-（苄基）-2,5-哌嗪二酮（5）对α-葡萄糖苷酶表现出较弱的抑制活性。
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