急性淋巴细胞白血病治疗期间侵袭性耳霉感染的成功治疗
Successful Treatment of Invasive Conidiobolus Infection During Therapy for Acute Lymphoblastic Leukemia.
作者信息
Erker Craig, Huppler Anna R, Walsh Thomas J, McCormick Michael E, Suchi Mariko, Bhatt Neel S, Kehl Susan C, Southwood Jessica, Harker-Murray Paul
机构信息
Departments of Pediatrics.
Transplantation-Oncology Infectious Diseases Program, Weill Cornell Medical Center of Cornell University, New York City, NY.
出版信息
J Pediatr Hematol Oncol. 2018 Oct;40(7):e446-e449. doi: 10.1097/MPH.0000000000000985.
Abstract
Invasive fungal infections are a serious cause of morbidity and mortality in patients with hematologic malignancies. Conidiobolus species are molds within the order Entomophthorales and may disseminate to become rapidly fatal in immunocompromised individuals. This species of fungal infections are often multidrug resistant (MDR) and present unique therapeutic challenges. Reports of Conidiobolus infections are rare in pediatric oncology. We report the successful treatment of an adolescent male with B-cell lymphoblastic leukemia and MDR invasive sinopulmonary Conidiobolus infection with emphasis on early and aggressive neutrophil support with surgical debridement. The strategies described could be applied to other MDR fungal infections.
摘要
侵袭性真菌感染是血液系统恶性肿瘤患者发病和死亡的严重原因。耳霉属真菌是虫霉目内的霉菌，在免疫功能低下的个体中可能播散并迅速致命。这种真菌感染通常具有多重耐药性（MDR），并带来独特的治疗挑战。在儿科肿瘤学中，耳霉属感染的报告很少。我们报告了一名患有B细胞淋巴细胞白血病和多重耐药性侵袭性鼻窦肺部耳霉属感染的青少年男性的成功治疗，重点是早期积极的中性粒细胞支持和手术清创。所描述的策略可应用于其他多重耐药性真菌感染。
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