Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, P.R. China.
Chemistry. 2018 Jan 9;24(2):409-415. doi: 10.1002/chem.201703833. Epub 2017 Dec 4.
Peroxidase-mimicking nanozymes offer unique advantages in terms of high stability and low cost over natural peroxidase for applications in bioanalysis, biomedicine, and the treatment of pollution. However, the design of high-efficiency peroxidase-mimicking nanozymes remains a great challenge. In this study, we adopted a structural-design approach through hybridization of cube-CeO and Pt nanoparticles to create a new peroxidase-mimicking nanozyme with high efficiency and excellent stability. Relative to pure cube-CeO and Pt nanoparticles, the as-hybridized Pt/cube-CeO nanocomposites display much improved activities because of the strong metal-support interaction. Meanwhile, the nanocomposites also maintain high catalytic activity after long-term storage and multiple recycling. Based on their excellent properties, Pt/cube-CeO nanocomposites were used to construct high-performance colorimetric biosensors for the sensitive detection of metabolites, including H O and glucose. Our findings highlight opportunities for the development of high-efficiency peroxidase-mimicking nanozymes with potential applications such as diagnostics, biomedicine, and the treatment of pollution.
过氧化物酶模拟纳米酶在生物分析、生物医学和污染处理等应用方面具有比天然过氧化物酶更高的稳定性和更低的成本，提供了独特的优势。然而，设计高效的过氧化物酶模拟纳米酶仍然是一个巨大的挑战。在这项研究中，我们采用了结构设计方法，通过立方氧化铈和铂纳米粒子的杂交，创造了一种具有高效和优异稳定性的新型过氧化物酶模拟纳米酶。与纯立方氧化铈和铂纳米粒子相比，由于强的金属-载体相互作用，杂交后的 Pt/cube-CeO 纳米复合材料显示出了更高的活性。同时，纳米复合材料在长期储存和多次回收后仍保持高的催化活性。基于其优异的性能，Pt/cube-CeO 纳米复合材料被用于构建高性能比色生物传感器，用于敏感检测代谢物，包括 H2O2和葡萄糖。我们的研究结果为开发高效的过氧化物酶模拟纳米酶提供了机会，这些纳米酶具有诊断、生物医学和污染处理等潜在应用。
