• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

大的单一单位剂型的胃排空

Gastric emptying of large single unit dosage forms.

作者信息

Davis S S, Norring-Christensen F, Khosla R, Feely L C

机构信息

Department of Pharmacy, University of Nottingham, University Park, UK.

出版信息

J Pharm Pharmacol. 1988 Mar;40(3):205-7. doi: 10.1111/j.2042-7158.1988.tb05220.x.

DOI:10.1111/j.2042-7158.1988.tb05220.x
PMID:2899152
Abstract

The gastrointestinal transit of two single unit dosage forms has been followed in healthy subjects under different feeding conditions. Transit was affected by the size of the meal administered. When two tablets were given concurrently they often emptied from the stomach at or about the same time, but in a number of cases the two units were seen to empty at widely different times.

摘要

在不同进食条件下,对健康受试者体内两种单一剂型的胃肠道转运情况进行了跟踪研究。转运情况受所进食物量大小的影响。同时服用两片药时,它们通常会在大致相同的时间从胃中排空,但在许多情况下,这两个单位剂型会在相差很大的时间内排空。

相似文献

1
Gastric emptying of large single unit dosage forms.大的单一单位剂型的胃排空
J Pharm Pharmacol. 1988 Mar;40(3):205-7. doi: 10.1111/j.2042-7158.1988.tb05220.x.
2
Transit of pharmaceutical dosage forms through the small intestine.药物剂型在小肠中的转运。
Gut. 1986 Aug;27(8):886-92. doi: 10.1136/gut.27.8.886.
3
Analysis of small intestinal transit and colon arrival times of non-disintegrating tablets administered in the fasted state.空腹状态下服用的不崩解片剂的小肠转运时间和结肠到达时间分析。
Eur J Pharm Sci. 2015 Jul 30;75:131-41. doi: 10.1016/j.ejps.2015.03.001. Epub 2015 Mar 11.
4
Meal-induced acceleration of tablet transit through the human small intestine.进餐引起的片剂在人体小肠内转运加速。
Pharm Res. 2009 Feb;26(2):356-60. doi: 10.1007/s11095-008-9749-2. Epub 2008 Nov 4.
5
The gastric emptying of food as measured by gamma-scintigraphy and electrical impedance tomography (EIT) and its influence on the gastric emptying of tablets of different dimensions.通过γ闪烁扫描法和电阻抗断层成像(EIT)测量的食物胃排空及其对不同尺寸片剂胃排空的影响。
J Pharm Pharmacol. 2007 Nov;59(11):1527-36. doi: 10.1211/jpp.59.11.0010.
6
Gastrointestinal transit of model mini-tablet controlled release oral dosage forms in fasted human volunteers.模型微型片剂控释口服剂型在空腹人类志愿者体内的胃肠道转运。
J Pharm Pharmacol. 2007 Jul;59(7):941-5. doi: 10.1211/jpp.59.7.0005.
7
Effects of Diurnal Variation and Food on Gastrointestinal Transit of In-Labeled Hydrogel Matrix Extended-Release Tablets and Tc-Labeled Pellets in Humans.人体标记水凝胶基质控释片和 Tc 标记微丸的胃肠道转运的昼夜变化和食物影响。
J Pharm Sci. 2020 Feb;109(2):1020-1025. doi: 10.1016/j.xphs.2019.09.025. Epub 2019 Oct 7.
8
Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects.健康受试者中药物剂型胃肠道转运的差异。
Pharm Res. 1991 Mar;8(3):360-4. doi: 10.1023/a:1015849700421.
9
Understanding the in vivo performance of enteric coated tablets using an in vitro-in silico-in vivo approach: case example diclofenac.采用体内-体外-体内模拟方法理解肠溶片剂的体内性能:案例分析双氯芬酸。
Eur J Pharm Biopharm. 2013 Nov;85(3 Pt B):1337-47. doi: 10.1016/j.ejpb.2013.09.009. Epub 2013 Sep 18.
10
Gastroretentive dosage forms.胃滞留剂型
Crit Rev Ther Drug Carrier Syst. 1993;10(2):143-95.

引用本文的文献

1
Pharmacokinetic study of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement product.新型口服 S-腺苷甲硫氨酸(MSI-195)制剂在健康受试者中的药代动力学研究:剂量递增、食物影响及与市售营养补充剂产品的比较。
BMC Pharmacol Toxicol. 2020 Dec 14;21(1):88. doi: 10.1186/s40360-020-00466-7.
2
A Quantitative Review and Meta-models of the Variability and Factors Affecting Oral Drug Absorption-Part II: Gastrointestinal Transit Time.影响口服药物吸收的变异性及因素的定量综述与元模型——第二部分:胃肠道转运时间
AAPS J. 2016 Sep;18(5):1322-1333. doi: 10.1208/s12248-016-9953-7. Epub 2016 Jul 20.
3
Gastrointestinal transit, release and plasma pharmacokinetics of a new oral budesonide formulation.
一种新型口服布地奈德制剂的胃肠道转运、释放及血浆药代动力学
Br J Clin Pharmacol. 2006 Jan;61(1):31-8. doi: 10.1111/j.1365-2125.2005.02517.x.
4
Erythromycin accelerates solid emptying at the expense of gastric sieving.红霉素以牺牲胃筛分功能为代价加速固体排空。
Dig Dis Sci. 1994 Jan;39(1):124-8. doi: 10.1007/BF02090071.
5
Relationship between the rate of appearance of oxprenolol in the systemic circulation and the location of an oxprenolol Oros 16/260 drug delivery system within the gastrointestinal tract as determined by scintigraphy.通过闪烁扫描法测定心得舒在体循环中的出现速率与心得舒渗透泵型16/260给药系统在胃肠道内位置之间的关系。
Br J Clin Pharmacol. 1988 Oct;26(4):435-43. doi: 10.1111/j.1365-2125.1988.tb03403.x.
6
Biochemical and mechanical characterization of enzyme-digestible hydrogels.酶可消化水凝胶的生化与力学特性
Pharm Res. 1990 Aug;7(8):816-23. doi: 10.1023/a:1015956714669.
7
Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects.健康受试者中药物剂型胃肠道转运的差异。
Pharm Res. 1991 Mar;8(3):360-4. doi: 10.1023/a:1015849700421.
8
Relationship between systemic drug absorption and gastrointestinal transit after the simultaneous oral administration of carbamazepine as a controlled-release system and as a suspension of 15N-labelled drug to healthy volunteers.将卡马西平制成控释制剂并以15N标记药物的混悬液同时口服给健康志愿者后,全身药物吸收与胃肠转运之间的关系。
Br J Clin Pharmacol. 1991 Nov;32(5):573-9. doi: 10.1111/j.1365-2125.1991.tb03954.x.
9
Correlation of the gastric emptying of nondisintegrating tablets with gastrointestinal motility.不崩解片剂的胃排空与胃肠动力的相关性
Pharm Res. 1991 Oct;8(10):1281-5. doi: 10.1023/a:1015855829864.
10
Gamma scintigraphy in the evaluation of pharmaceutical dosage forms.γ闪烁扫描术在药物剂型评价中的应用
Eur J Nucl Med. 1992;19(11):971-86. doi: 10.1007/BF00175865.