来自非洲榄仁树的两种新的黄烷素型柠檬苦素酯。

Two new phragmalin-type limonoids orthoesters from Entandrophragma candollei.

机构信息

State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China; Centre for Plant Medicine Research, P.O. Box 73, Mampong-Akwapim, Ghana.

State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.

出版信息

Chin J Nat Med. 2017 Sep;15(9):680-683. doi: 10.1016/S1875-5364(17)30097-3.

DOI:10.1016/S1875-5364(17)30097-3

PMID:28991529

Abstract

Two new phragmalin-type limonoids orthoesters, encandollens A and B (1 and 2), were isolated from the stem barks of Entandrophragma candollei collected in Ghana. The structures of these compounds were elucidated on the basis of HR-ESI-MS, H and C NMR, HSQC, HMBC, and ROESY data. Compound 1 was a rare C-15 enolic acyl phragmalin-type limonoid orthoester. Compounds 1 and 2 exhibited weak inhibitory effects on NO production in lipopolysaccharide (LPS)-induced RAW 264.7 cells.

摘要

从加纳采集的恩檀多法木属植物茎皮中分离得到两种新的黄烷醇型柠檬苦素原酯，分别命名为encandollens A 和 B（1 和 2）。基于高分辨电喷雾电离质谱（HR-ESI-MS）、氢谱（1H-NMR）、碳谱（13C-NMR）、异核单量子相关谱（HSQC）、HMBC 谱和 ROESY 谱等数据，鉴定了这两种化合物的结构。化合物 1 是一种罕见的 C-15 烯醇酰基黄烷醇型柠檬苦素原酯。化合物 1 和 2 对脂多糖（LPS）诱导的 RAW 264.7 细胞中一氧化氮（NO）的产生表现出较弱的抑制作用。