氧氟沙星肠道吸收的动力学机制。 （注：原文中“of ofloxacin”多了一个“of”）
Kinetic mechanism for the intestinal absorption of ofloxacin.
作者信息
Prieto J G, Barrio J P, Alvarez A I, Gómez G
机构信息
Laboratory of Animal Physiology, Faculty of Biology, University of Leon, Spain.
出版信息
J Pharm Pharmacol. 1988 Mar;40(3):211-2. doi: 10.1111/j.2042-7158.1988.tb05223.x.
Abstract
The absorptive behaviour of ofloxacin, a quinolone antibacterial agent, was studied following recirculation in small intestine of both male and female rats, at initial doses ranging from 0.125 to 5 mg mL-1. A saturable Michaelis-Menten process is suggested to explain the intestinal absorption. No significant differences were found in the absorption parameters per metabolic weight unit.
摘要
喹诺酮类抗菌剂氧氟沙星在雄性和雌性大鼠小肠再循环后的吸收行为，以0.125至5毫克/毫升的初始剂量进行了研究。有人提出用饱和的米氏过程来解释肠道吸收。在每代谢体重单位的吸收参数上未发现显著差异。
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