Wijnands W J, Vree T B, Baars A M, van Herwaarden C L
Department of Pulmonary Diseases, Medical Centre Dekkerswald, University of Nijmegen.
Drugs. 1987;34 Suppl 1:159-69. doi: 10.2165/00003495-198700341-00034.
Some of the new quinolone derivatives may be of value in the treatment of respiratory tract infections. It has been demonstrated that enoxacin, pefloxacin and ciprofloxacin, but not ofloxacin, decreased the metabolic clearance of the bronchodilator theophylline. This resulted in elevated plasma theophylline concentrations and, in some of the patients, theophylline toxicity. When the pharmacokinetic parameters of enoxacin, pefloxacin, ciprofloxacin and ofloxacin obtained in the present study were compared with those obtained from other studies in healthy volunteers not given concomitant theophylline, there was no evidence of theophylline influencing the clearance of the investigated quinolones.
一些新的喹诺酮衍生物可能在治疗呼吸道感染方面具有价值。已证实依诺沙星、培氟沙星和环丙沙星，但氧氟沙星不会降低支气管扩张剂茶碱的代谢清除率。这导致血浆茶碱浓度升高，并且在一些患者中出现了茶碱毒性。当将本研究中获得的依诺沙星、培氟沙星、环丙沙星和氧氟沙星的药代动力学参数与未同时给予茶碱的健康志愿者的其他研究中获得的参数进行比较时，没有证据表明茶碱会影响所研究喹诺酮类药物的清除率。
