Neuroscience Branch, Interdisciplinary Laboratory of Medical Investigation, School of Medicine, UFMG, Belo Horizonte, Brazil.
Neuromuscular Disease Clinic, University Hospital, UFMG, Belo Horizonte, Brazil.
J Neurol Sci. 2017 Oct 15;381:169-175. doi: 10.1016/j.jns.2017.08.3250. Epub 2017 Aug 24.
This study aimed to evaluate changes in body composition, i.e. overweight, obesity, fat accumulation and low lean body mass and plasma levels of adipokines in patients with MG. The study enrolled 80 patients with MG, and 62 controls. Body fat mass and body lean mass was analyzed by dual-energy X-ray absorptiometry technique (DXA). Plasma levels of leptin were analyzed by Luminex® and adiponectin and resistin were analyzed by ELISA. The mean age of patients with MG was 41.9years, with 13.5years of length of illness, and mean cumulative dose of glucocorticoids 38,123mg. Our results showed that the frequency of obesity is higher in MG patients than in controls, and patients with MG presented higher body fat mass, android body adiposity and total body fat than controls. MG patients presented lower levels of resistin and higher levels of leptin in comparison with controls. There were no differences in the plasma levels of adiponectin. Higher total body fat and lower body lean mass were associated with increased severity of MG symptoms. This result points to the relevance of estimation of body composition in planning long-term care of MG patients.
本研究旨在评估 MG 患者的身体成分变化，即超重、肥胖、脂肪堆积和低瘦体重以及血浆脂联素水平的变化。该研究纳入了 80 例 MG 患者和 62 名对照。采用双能 X 线吸收仪（DXA）分析体脂肪量和体瘦体重。采用 Luminex®分析瘦素水平，采用 ELISA 分析脂联素和抵抗素水平。MG 患者的平均年龄为 41.9 岁，病程 13.5 年，累积糖皮质激素剂量为 38,123mg。结果显示，MG 患者的肥胖发生率高于对照组，MG 患者的体脂肪量、腹型肥胖和全身脂肪均高于对照组。与对照组相比，MG 患者的抵抗素水平较低，瘦素水平较高。脂联素的血浆水平无差异。全身脂肪量越高，体瘦体重越低，与 MG 症状严重程度增加相关。该结果提示在制定 MG 患者的长期护理计划时，评估身体成分具有重要意义。
