Enteric Disease Department, Infectious Disease Directorate, Naval Medical Research Center, Silver Spring, Maryland.
Biological Defense Research Directorate, Naval Medical Research Center, Fort Detrick, Maryland.
J Pediatric Infect Dis Soc. 2018 Aug 17;7(3):253-256. doi: 10.1093/jpids/pix056.
Here, we report a complex case that involved a pediatric patient who experienced recalcitrant multidrug-resistant Pseudomonas aeruginosa infection complicated by bacteremia/sepsis; our antibacterial options were limited because of resistance, allergies, and suboptimal source control. A cocktail of 2 bacteriophages targeting the infectious organism introduced on 2 separate occasions sterilized the bacteremia.
在这里,我们报告了一个复杂的病例,涉及到一名患有顽固性多重耐药铜绿假单胞菌感染并伴有菌血症/败血症的儿科患者;由于耐药性、过敏和不理想的源头控制,我们的抗菌选择有限。分两次引入的针对感染病原体的 2 种噬菌体鸡尾酒疗法使菌血症得到了清除。