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噬菌体治疗后 2 岁幼儿发生耐药铜绿假单胞菌菌血症

Refractory Pseudomonas Bacteremia in a 2-Year-Old Sterilized by Bacteriophage Therapy.

机构信息

Enteric Disease Department, Infectious Disease Directorate, Naval Medical Research Center, Silver Spring, Maryland.

Biological Defense Research Directorate, Naval Medical Research Center, Fort Detrick, Maryland.

出版信息

J Pediatric Infect Dis Soc. 2018 Aug 17;7(3):253-256. doi: 10.1093/jpids/pix056.

Abstract

Here, we report a complex case that involved a pediatric patient who experienced recalcitrant multidrug-resistant Pseudomonas aeruginosa infection complicated by bacteremia/sepsis; our antibacterial options were limited because of resistance, allergies, and suboptimal source control. A cocktail of 2 bacteriophages targeting the infectious organism introduced on 2 separate occasions sterilized the bacteremia.

摘要

在这里,我们报告了一个复杂的病例,涉及到一名患有顽固性多重耐药铜绿假单胞菌感染并伴有菌血症/败血症的儿科患者;由于耐药性、过敏和不理想的源头控制,我们的抗菌选择有限。分两次引入的针对感染病原体的 2 种噬菌体鸡尾酒疗法使菌血症得到了清除。

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